中国医院用药评价与分析2023，Vol.23Issue(12)：1473-1477,1483,6.DOI:10.14009/j.issn.1672-2124.2023.12.013
复方金钱草颗粒治疗泌尿系结石术后的有效性和安全性的Meta分析
Meta-Analysis on Efficacy and Safety of Fufang Jinqiancao Granules in the Treatment of Urinary Calculi After Surgery
摘要
Abstract
OBJECTIVE:To systematically review the efficacy and safety of Fufang Jinqiancao granules in the treatment of urinary calculi after surgery.METHODS:CNKI,Wanfang Data,VIP,CBM,PubMed,the Cochrane Library,Embase and Wed of Science were retrieved to collect the randomized controlled trials of Fufang Jinqiancao granules in the treatment of urinary calculi after surgery,the retrieval time was from the establishment of the database to Jan.2023.Meta-analysis was performed by using RevMan 5.4 software.RESULTS:Totally 10 articles were included.The results of Meta-analysis showed that the total effective rate of the Fufang Jinqiancao granules group was higher than that of the blank control group for patients without indenture of double J tubes after surgery,and the difference was statistically significant(RR=1.18,95%CI=1.09-1.27,P<0.000 1).On the basis of conventional treatment,in combination with Fufang Jinqiancao granules,the international prostate symptom score(IPSS)(MD=-2.81,95%CI=-3.25--2.36,P<0.000 01)and overactive bladder syndrome score(OABSS)(MD=-3.48,95%CI=-5.64--1.33,P=0.002)of patients with urinary calculi after surgery was better than the conventional treatment alone,with statistically significant difference.Compared with the blank control and anti-infection treatment alone,Fufang Jinqiancao granules and its combination with anti-infection treatment could reduce the incidence of postoperative complications in patients with indenture double J-tube,with statistically significant difference(RR=0.29,95%CI=0.12-0.72,P = 0.008).Compared with the blank control and levofloxacin,Fufang Jinqiancao granules could shorten the postoperative stone expulsion time,and the differences were statistically significant(P<0.05).Compared with anti-infection treatment alone,the time of stone removal in patients treated with Fufang Jinqiancao granules after surgery was shorter,and the difference was statistically significant(P<0.01).CONCLUSIONS:Fufang Jinqiancao granules can increase the total effective rate of urinary calculi after surgery,improve IPSS score and OABSS score,shorten the postoperative stone expulsion time,reduce the complications caused by indindent double J-tubes,without severe adverse drug reactions.关键词
复方金钱草颗粒/泌尿系结石/Meta分析Key words
Fufang Jinqiancao granules/Urinary calculi/Meta-analysis分类
医药卫生引用本文复制引用
席俊羽,刘亚芬,黎元元,谢雁鸣..复方金钱草颗粒治疗泌尿系结石术后的有效性和安全性的Meta分析[J].中国医院用药评价与分析,2023,23(12):1473-1477,1483,6.基金项目
国家中医药管理局2021年岐黄学者支持项目(No.国中医药人教函[2022]6号) （No.国中医药人教函[2022]6号）
中国民族医药学会科研项目(No.2020ZY378-130101) （No.2020ZY378-130101）
