中国医院用药评价与分析2023，Vol.23Issue(12)：1521-1523,1527,4.DOI:10.14009/j.issn.1672-2124.2023.12.023
25例儿童患者应用免疫检查点抑制剂的不良反应调查和分析
Investigation and Analysis of Adverse Drug Reactions Induced by Immune Checkpoint Inhibitors in 25 Children
摘要
Abstract
OBJECTIVE:To investigate and analyze the adverse drug reactions induced by immune checkpoint inhibitors in children.METHODS:Retrospective investigation was performed on medical records of 25 children(<18 years old)who received programmed death-1(PD-1)/programmed death-ligand 1(PD-L1)inhibitors for treatment of various malignant solid tumors and hematologic tumors in the hospital from Jan.1st,2019 to Sept.15th,2022(totally 137 admissions records).All adverse drug reactions occurred during treatment were recorded,and severity classification,correlation evaluation and influencing factors analysis were performed.RESULTS:Of 25 children treated with PD-1/PD-L1 inhibitors,20 adverse drug reactions occurred in 16 patients.The main adverse drug reactions were fever(8 cases,32%),elevated aminotransferase(3 cases,12%)and coagulation dysfunction(2 cases,8%),in addition to decreased white blood cell count,cough,rash,diarrhea,fecal occult blood,fatigue and loss of appetite(1 case each,4%).There were 19 adverse drug reactions of grade 1 to 2 and 1 adverse drug reaction of grade 3 to 5,and the correlation was"highly likely"for a total of 15 times.Four patients were retreated after the occurrence of adverse drug reactions,and two patients developed new adverse drug reactions.After analysis,complications involving 3 or more systems had a significant impact on the incidence of adverse drug reactions.CONCLUSIONS:The occurrence of adverse drug reactions in children with PD-1/PD-L1 inhibitors differs from that of adults and requires more attention than in adults.Clinical attention should be paid to drug monitoring to improve the safety of drug use in children.关键词
儿童/程序性死亡受体1/程序性死亡受体配体1抑制剂/免疫治疗/不良反应/相关性评价Key words
Children/Programmed death receptor 1/pogrammed death receptor ligand 1 inhibitors/Immuno-therapy/Adverse drug reactions/Correlation evaluation分类
医药卫生引用本文复制引用
杜丰,李哲,郑英明,李新刚..25例儿童患者应用免疫检查点抑制剂的不良反应调查和分析[J].中国医院用药评价与分析,2023,23(12):1521-1523,1527,4.基金项目
北京市自然科学基金资助项目(No.7192060) （No.7192060）
