外周血miRNA-126与miRNA-143表达对颅内动脉瘤介入术后患者复发的预测价值OACSTPCD

Objective:To explore the predictive value of peripheral blood microRNA-126(miRNA-126)and miRNA-143 for re-currence in patients with intracranial aneurysm after interventional surgery.Methods:A total of 113 patients with intracranial aneurysms undergoing interventional embolization were selected as the research objects.According to different Raymond grades,they were divided into Raymond Ⅰ group(n =88),Raymond Ⅱ group(n =13)and Raymond Ⅲ group(n =12),according to different prognoses,they were divided into a recurrent group(n =19)and a non recurrent group(n =94).The expression levels of miRNA-126 and miRNA-143 in peripheral blood of patients with different grades and prognoses were compared,and their correlation with Raymond grade,and predict their predictive value for postoperative recurrence in patients with intracranial aneurysms undergoing interventional embolization were analyzed.Results:Compared with patients with Raymond grading at grade I,miRNA-126 level was increased(P<0.05),while miRNA-143 level was decreased in those at grades Ⅱ and Ⅲ(P<0.05).Correlation analysis showed that the levels of miRNA-126 were positively correlated with Raymond grading(r =0.364,P<0.05),while miRNA-143 levels were negatively correlated with Ray-mond grading(r =-0.347,P<0.05).The level of peripheral blood miRNA-126 in recurrence group was higher than that in non-re-currence group(P<0.05),while miRNA-143 level was lower than that in non-recurrence group(P<0.05).ROC curve analysis showed that the area under the curve(AUC)values of peripheral blood miR-126,miR-143 and combined detection for predicting post-operative recurrence were 0.767,0.826 and 0.968,respectively.AUC of combined detection was greater than that of single index(P<0.05).Conclusion:The peripheral blood miRNA-126 combined with miRNA-143 can improve the predictive value for recurrence of in-tracranial aneurysm after interventional surgery.