川北医学院学报2024，Vol.39Issue(1)：30-33,50,5.DOI:10.3969/j.issn.1005-3697.2024.01.007
不同剂量瑞马唑仑对肝内外胆管结石手术患者麻醉效果及血流动力学影响
Effects of different doses of remazolam on anesthesia effect and hemody-namics in patients undergoing surgery for intrahepatic and extrahepatic bile duct stones
摘要
Abstract
Objective:To investigate the effects of different doses of remazolam on anesthesia effect and hemodynamics in pa-tients undergoing intrahepatic and extrahepatic bile duct stone surgery.Methods:All 103 patients undergoing intrahepatic and extrahe-patic bile duct stone surgery were anesthesiated by remazolam and divided into low-dose group(0.2 mg/kg,n =52)and high-dose group(0.3 mg/kg,n =51)according to anesthesia dose.The anesthesia effect,analgesic effect,oxidative stress,hemodynamics,and ad-verse reactions of the two groups were compared.Results:The extubation time and awakening time in the low-dose group were shorter than those in the high-dose group(P<0.05).After anesthesia,the Ramsay score of both groups gradually increased with time,and the Ramsay score in the low-dose group was lower than that in the high-dose group at 15 minutes of anesthesia and 30 minutes of anesthesia(P<0.05).In both groups,the VAS scores of the high-dose group were lower than those in the low-dose group at 6,12 and 24 h after surgery,and the VAS score in both groups increased first and then decreased with time(P<0.05).1 day after surgery,the levels of hy-drogen peroxide(H2 O2),human cortisol(Cor)and malondialdehyde(MDA)in both groups were higher than those before surgery,and the levels of indexes in the low-dose group were lower than those in the high-dose group(P<0.05).15 minutes after anesthesia,diastolic blood pressure,systolic blood pressure and heart rate levels increased in both groups,oxygen saturation decreased in the high-dose group,and diastolic blood pressure,systolic blood pressure and heart rate in the low-dose group were lower than those in the high-dose group,and the oxygen saturation was higher than that in the high-dose group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Both doses of remazolam anesthesia have high anesthe-sia,sedation and analgesic effects,but high-dose anesthesia is easy to lead to large hemodynamic fluctuations and cause greater stress response in patients,so it is safer to use low-dose anesthesia for intrahepatic and extrahepatic bile duct stone surgery.关键词
瑞马唑仑/肝内外胆管结石/麻醉效果/血流动力学Key words
Remazolam/Intrahepatic and extrahepatic bile duct stones/Anesthetic effect/Hemodynamics分类
医药卫生引用本文复制引用
史劲飞,汤洁,戴筱筱,孙登群..不同剂量瑞马唑仑对肝内外胆管结石手术患者麻醉效果及血流动力学影响[J].川北医学院学报,2024,39(1):30-33,50,5.基金项目
安徽省自然科学基金(1908085MH261) （1908085MH261）
