川北医学院学报2024，Vol.39Issue(1)：38-41,4.DOI:10.3969/j.issn.1005-3697.2024.01.009
胎盘绒毛跨膜蛋白CD81、Ang与复发性流产女性早孕期复发流产的关系
Relationship between placental villi transmembrane protein CD81,Ang levels and recurrent abortion in early pregnancy of women with recurrent spontaneous abortion
摘要
Abstract
Objective:To investigate the relationship between the levels of placental villi transmembrane protein CD81,angiopoi-etin(Ang)and recurrent abortion in early pregnancy of women with recurrent spontaneous abortion(RSA).Methods:126 patients with RSA(RSA group)and 94 subjects with normal early pregnancy(control group)were selected.The mRNA and protein expression levels of CD81,Ang-1 and Ang-2 in placental villi tissues were detected by real-time fluorescence quantitative polymerase chain reaction and Western blot,and levels of serum human chorionic gonadotropin(HCG)was detected by electrochemiluminescence method.The mRNA and protein expression ratios of Ang-1/Ang-2 were calculated,and the detection results were compared.Results:The mRNA and protein expression levels of CD81,Ang-1 and Ang-2 in placental villi,Ang-1/Ang-2 mRNA ratio and Ang-1/Ang-2 protein expression ratio in RSA group were higher than those in control group,while the level of serum HCG was lower than that in control group(P<0.05).The CD81 mRNA in RSA group was positively correlated with the mRNA levels of Ang-1 and Ang-2(P<0.05).The protein expression of CD81 in RSA group was positively correlated with the protein expressions of Ang-1 and Ang-2(P<0.05),and serum HCG level was not correlated with the other indicators(P>0.05).The mRNA and protein expression levels of CD81 and Ang-1/Ang-2 and serum HCG could be used to predict recurrent abortion in women with RSA during early pregnancy.Conclusion:Recurrent abor-tion in early pregnancy of women with RSA is related to abnormal high mRNA and protein expressions of CD81,Ang-1 and Ang-2 in placental villi.CD81,Ang-1 and Ang-2 may affect placental angiogenesis and then lead to abortion.关键词
复发性流产/早孕期/胎盘绒毛/跨膜蛋白CD81/血管生成素/人绒毛膜促性腺激素Key words
Recurrent spontaneous abortion/Early pregnancy/Placental villi/Transmembrane protein CD81/Angiopoietin/Hu-man chorionic gonadotropin分类
医药卫生引用本文复制引用
张晓英,董小敏,赵盼盼,于芳..胎盘绒毛跨膜蛋白CD81、Ang与复发性流产女性早孕期复发流产的关系[J].川北医学院学报,2024,39(1):38-41,4.基金项目
陕西省科学技术发展计划项目(2008K15-02) （2008K15-02）
