川北医学院学报2024，Vol.39Issue(1)：42-45,4.DOI:10.3969/j.issn.1005-3697.2024.01.010
维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效
Effect of vitamin C-assisted azithromycin sequential therapy on children with mycoplasma pneumoniae pneumonia
摘要
Abstract
Objective:To investigate the effect of vitamin C-assisted azithromycin sequential therapy on children with mycoplas-ma pneumoniae pneumonia(MPP)and influence on immune function.Methods:106 children with MPP were selected as the study subjects,and were divided into the observation group(n =53,treated with vitamin C-assisted azithromycin sequential therapy)and the control group(n =53,treated with azithromycin short-term intravenous infusion)according to different treatment methods.Both groups were treated for 7 days.The efficacy,symptom relief time,lung function,immune function and adverse reactions were compared between the two groups.Results:After treatment,the total clinical effective rate in the observation group(98.11%)was higher than that in the control group(86.79%)(P<0.05).After treatment,the remission times of high fever,cough,lung rale and chest radiograph were low-er in the observation group(P<0.05).Before treatment,there was no statistically significant difference in the percentage of forced ex-piratory vital capacity(FVC),the percentage of forced expiratory vital capacity in one second(FEVl)and FEVl/FVC between the two groups(P>0.05).After treatment,FVC,FEVl,and FEVl/FVC in both groups of children increased,and the observation group was higher than the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of peripheral blood immunoglobulin IgA,IgM,and IgG between the two groups(P>0.05).After treatment,the levels of immunoglobulins IgA and IgG in the peripheral blood in both groups of children increased,and the observation group was higher than the control group(P<0.05).IgM levels decreased,and the observation group was lower than the control group(P<0.05).There was no statistically signifi-cant difference in the incidence of adverse reactions between the two groups of children during treatment(P>0.05).Conclusion:Az-ithromycin sequential therapy combined with vitamin C can improve the efficacy and immunity of children with mycoplasma pneumoniae pneumonia,and is worthy of clinical promotion.关键词
维生素C/阿奇霉素序贯疗法/肺炎支原体肺炎/免疫功能Key words
Vitamin C/Azithromycin sequential therapy/Mycoplasma pneumoniae pneumonia/Immune function分类
医药卫生引用本文复制引用
何娜,郑光强,黄娆,林科,陈耿浩,袁文霄..维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效[J].川北医学院学报,2024,39(1):42-45,4.基金项目
海南省卫生健康行业科研项目(20A200242) （20A200242）
