维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效OACSTPCD
Effect of vitamin C-assisted azithromycin sequential therapy on children with mycoplasma pneumoniae pneumonia
目的:探讨维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎(MPP)疗效及其对免疫功能的影响.方法:选取106 例MPP患儿为研究对象,按照治疗方式不同分为观察组和对照组,每组各53 例.观察组患者采用维生素C辅助阿奇霉素序贯疗法治疗;对照组采用阿奇霉素治疗,疗程均为7d.比较两组患儿临床疗效、症状缓解时间、肺功能、免疫功能及不良反应发生情况.结果:观察组患儿临床总有效率高于对照组(98.11%vs.86.79%,P<0.05).治疗后,观察组患儿高热、咳嗽、肺啰音、胸片缓解时间短于对照组(P<0.05).治疗前,两组患儿用力呼气肺活量占预计值百分比(FVC)、第1 秒用力呼气肺活量(FEVl)、FEVl/FVC无统计学差异(P>0.05);治疗后,两组患儿FVC、FEVl、FEVl/FVC均升高,且观察组高于对照组(P<0.05).治疗前,两组患儿外周血免疫球蛋白IgA、IgM、IgG水平无统计学差异(P>0.05);治疗后,两组患儿外周血IgA、IgG水平均升高,且观察组高于对照组(P<0.05);IgM水平均降低,且观察组低于对照组(P<0.05).两组患儿治疗期间不良反应发生率比较,差异无统计学意义(P>0.05).结论:阿奇霉素序贯疗法联合维生素C治疗儿童肺炎支原体肺炎能够提高疗效和免疫功能,值得临床推广.
Objective:To investigate the effect of vitamin C-assisted azithromycin sequential therapy on children with mycoplas-ma pneumoniae pneumonia(MPP)and influence on immune function.Methods:106 children with MPP were selected as the study subjects,and were divided into the observation group(n =53,treated with vitamin C-assisted azithromycin sequential therapy)and the control group(n =53,treated with azithromycin short-term intravenous infusion)according to different treatment methods.Both groups were treated for 7 days.The efficacy,symptom relief time,lung function,immune function and adverse reactions were compared between the two groups.Results:After treatment,the total clinical effective rate in the observation group(98.11%)was higher than that in the control group(86.79%)(P<0.05).After treatment,the remission times of high fever,cough,lung rale and chest radiograph were low-er in the observation group(P<0.05).Before treatment,there was no statistically significant difference in the percentage of forced ex-piratory vital capacity(FVC),the percentage of forced expiratory vital capacity in one second(FEVl)and FEVl/FVC between the two groups(P>0.05).After treatment,FVC,FEVl,and FEVl/FVC in both groups of children increased,and the observation group was higher than the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of peripheral blood immunoglobulin IgA,IgM,and IgG between the two groups(P>0.05).After treatment,the levels of immunoglobulins IgA and IgG in the peripheral blood in both groups of children increased,and the observation group was higher than the control group(P<0.05).IgM levels decreased,and the observation group was lower than the control group(P<0.05).There was no statistically signifi-cant difference in the incidence of adverse reactions between the two groups of children during treatment(P>0.05).Conclusion:Az-ithromycin sequential therapy combined with vitamin C can improve the efficacy and immunity of children with mycoplasma pneumoniae pneumonia,and is worthy of clinical promotion.
何娜;郑光强;黄娆;林科;陈耿浩;袁文霄
海口市妇幼保健院儿内科,海南 海口 570203海南省人民医院·海南医学院附属海南医院儿内科,海南 海口 570311
临床医学
维生素C阿奇霉素序贯疗法肺炎支原体肺炎免疫功能
Vitamin CAzithromycin sequential therapyMycoplasma pneumoniae pneumoniaImmune function
《川北医学院学报》 2024 (001)
42-45 / 4
海南省卫生健康行业科研项目(20A200242)
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