川北医学院学报2024，Vol.39Issue(1)：104-107,4.DOI:10.3969/j.issn.1005-3697.2024.01.025
超早期滋养性肠内营养联合高压氧治疗急性缺血性脑卒中的临床疗效
Effect of ultra-early nourishing enteral nutrition combined with hyperbaric oxygen therapy on clinical outcome
摘要
Abstract
Objective:To investigate the effects of ultra-early nourishing enteral nutrition(EN)combined with hyperbaric oxy-gen therapy(HBOT)on clinical outcome and serum Sestrin2 protein(Sestrin2)and human Parkinson's protein(PARK7)in patients with acute ischemic stroke(AIS).Methods:106 patients with AIS were selected and divided into observation group(n =51)and con-trol group(n =55)according to different treatment methods.Observation group were treated with ultra early nourishing EN combined with HBOT,control group were treated with conventional EN combined with HBOT.Neurological deficit score(NIHSS)and modified Rankin score(mRS)were used to evaluate all patients,and peripheral blood nutritional indices[albumin(ALB),prealbumin(PA)and hemoglobin(Hb)],Sestrin2/PARK7 expression levels and the occurrence of adverse events were compared between the two groups.Results:After treatment,NIHSS and mRS Scores in observation group were lower than those in control group,serum ALB,PA,Hb,PARK7 and Sestrin2 expression levels were higher than those in control group(P<0.05).The incidence of infection and gastroin-testinal bleeding in the observation group were 33.33%and 7.84%,respectively,which were lower than those in the control group(52.73%and 23.64%),and the difference was statistically significant(P<0.05).Conclusion:Ultra-early nourishing EN combined with HBOT has a good clinical effect on AIS patients,in which the decrease of serum Sestrin2 and PARK7 levels may be an important mechanism of this treatment.关键词
急性缺血性脑卒中/超早期滋养性肠内营养/高压氧/疗效/Sestrin2蛋白/人帕金森蛋白Key words
Acute ischemic stroke/Ultra early nourishing enteral nutrition/Hyperbaric oxygen/Curative effect/Sestrin2 protein/Human Parkinson's protein分类
医药卫生引用本文复制引用
王震,冯慧,周修五,付娟娟,潘化平..超早期滋养性肠内营养联合高压氧治疗急性缺血性脑卒中的临床疗效[J].川北医学院学报,2024,39(1):104-107,4.基金项目
江苏省南京医科大学科技发展项目(NMUB2020161) （NMUB2020161）
江苏省重点研发计划(社会发展)(BE2021618) （社会发展）
