重庆医学2024，Vol.53Issue(1)：1-4,10,5.DOI:10.3969/j.issn.1671-8348.2024.01.001
肠道菌群在银屑病治疗中的研究进展
Research progress of gut microbiome in the treatment of psoriasis
文渚媛 1王萍 1陈爱军1
作者信息
- 1. 重庆医科大学附属第一医院皮肤科,重庆 400016
- 折叠
摘要
Abstract
Psoriasis is a chronic,recurrent,systemic inflammatory skin disease that is immune-media-ted.The balance and communication between the intestinal microbiota and its metabolites and the host play an important role in maintaining the body's normal functions,such as immune homeostasis and vitamin synthe-sis.Recent studies have found that compared with the healthy individuals,the psoriasis patients have experi-enced significant changes in the abundance and diversity of intestinal microbiota,including an imbalance in in-testinal microbiota,reduced production of short-chain fatty acids(SCFAs),and abnormal Firmicutes/Bacte-roidetes(F/B)ratio.The gut microbiota also changed after systematic medication treatment,biologic agents treatment and small molecule chemotherapy,indicating that the gut microbiota could be a potential biomarker for assessing treatment efficacy.The relationship between psoriasis and gut microbiota is not fully under-stood,and further research is needed.关键词
银屑病/肠道菌群/益生菌/生物制剂Key words
psoriasis/gut microbiome/probiotics/biologics分类
医药卫生引用本文复制引用
文渚媛,王萍,陈爱军..肠道菌群在银屑病治疗中的研究进展[J].重庆医学,2024,53(1):1-4,10,5.
