重庆医学2024，Vol.53Issue(1)：11-16,6.DOI:10.3969/j.issn.1671-8348.2024.01.003
放射性碘难治性分化型甲状腺癌的临床病理特征
Clinicopathological features of radioactive iodine-refractory differentiated thyroid cancer
摘要
Abstract
Objective To investigate the clinicopathological characteristics of radioactive Iodine-refrac-tory differentiated thyroid cancer(RAIR-DTC)to provide a clinical evidence for early prediction of the thyroid cancer patients with radioactive Iodine-refractory(RAIR).Methods The data of 84 patients with undergoing thyroidectomy and 131I therapy in PLA 960 hospital from January 2010 to December 2019 were retrospectively analyzed.Thirty-nine patients with diagnosed RAIR-DTC served as the study group and 45 cases of radioactive iodine-avid differentiated thyroid cancer(RAIA-DTC)served as the control group.The clinicopathological characteristics were compared between the two groups.The logistic regression was used to analyze the inde-pendent risk factors of RAIR-DTC,and the RAIR-DTC prediction model was established.Results Compared with the RAIA-DTC group,the RAIR-DTC group had more iodine treatment times,the proportions of the pa-tients with age ≥55 years old,total iodine therapeutic dose,distant metastasis,TNM stage Ⅳ,high-risk sub-types and focal calcification were higher,the tumor maximum diameter was greater,the number of lymph node metastases was more and the probability of Ⅱ,Ⅰ+Ⅱ and non-central lymph node metastases was higher(P＞0.05).The progression-free survival rate had statistical difference between the two groups(P＜0.05).The total survival rate had no statistical difference between the two groups(P＞0.05).The binary logistic re-gression analysis results showed that the distant metastasis,high-risk histological subtype and maximum tumor diameter ≥10.5 mm were the independent risk factors for RAIR-DTC.The obtained fitting equation logit(P)=-2.259+3.330X1+2.287X2+1.606X3,the ROC curve was used to calculate the truncation val-ue of the fitted equation as-0.312 5,when logit(P)＞-0.312 5,it might develop into RAIR-DTC.Conclusion The clinicopathological characteristics of the patients with differentiated thyroid cancer could ef-fectively predict RAIR.关键词
分化型甲状腺癌/放射性碘难治/乳头状癌/滤泡性癌/远处转移Key words
differentiated thyroid carcinoma/Iodine-refractory/papillary thyroid carcinoma/follicular carcinoma/distant metastasis分类
医药卫生引用本文复制引用
姜贝贝,李帅,刘稳,薛景丽,李敏,李培峰..放射性碘难治性分化型甲状腺癌的临床病理特征[J].重庆医学,2024,53(1):11-16,6.基金项目
山东省自然科学基金面上项目(ZR2023MH029) （ZR2023MH029）
山东省医药卫生科技发展计划项目(202201041061). （202201041061）
