重庆医学2024，Vol.53Issue(1)：102-107,113,7.DOI:10.3969/j.issn.1671-8348.2024.01.021
益生菌联合饮食干预对妊娠期糖尿病糖脂代谢及妊娠结局的影响
Effects of probiotics combined with dietary intervention on glucose and lipid metabolism and pregnancy outcome in gestational diabetes mellitus
摘要
Abstract
Objective To investigate the effects of probiotics combined with dietary intervention on pe-ripheral blood glucose and lipid metabolism indicators,placental tissue insulin signaling pathway proteins ex-pression and pregnant outcome in the patients with gestational diabetes mellitus(GDM).Methods A total of 83 patients with GDM in this hospital from December 2021 to December 2022 were selected as the study sub-jects and divided into the probiotics group(probiotics combined with diet intervention,43 cases)and control group(simple diet intervention,40 cases)by the random number table method.The levels of peripheral blood glucose,lipid and insulin resistance related indicators before the intervention and in 8 weeks after the interven-tion were compared between the two groups.The histological changes of placenta were observed by HE stai-ning.The pathological indicators were compared between the two groups.The expression levels of insulin re-ceptor substrate-1(IRS-1),glucose transporter 4(GLUT4)and synaptosome-associated protein of 23 kDa(SNAP23)in placental tissue were detected by immunohistochemistry.The pregnant adverse outcomes were compared between the two groups,and the clinical efficacy of probiotics was evaluated.Results Compared with the control group,the levels of fasting blood glucose(FBG),fasting insulin(FINS),serum triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in 8 weeks after intervention in the probiotics group were significantly decreased(P＜0.05),and the level of serum high density lipoprotein cholesterol(HDL-C)was significantly increased(P＜0.05).There were no significant differences in the incidence rates of poor villi maturation,thickening of dry villi arterioles and capillary filling in villi interstitial between the two groups(P＞0.05).Compared with the control group,the expression levels of IRS-1,GLUT4 and SNAP23 in placen-tal tissue of the probiotics group were significantly increased(P＜0.05).The incidence rates of neonatal hy-poglycemia and neonatal hyperbilirubinemia in the probiotics group were significantly lower than those in the control group(P＜0.05).Conclusion Compared with simple dietary intervention,probiotics combined with dietary intervention has more advantages in improving glucose and lipid metabolism of GDM patients,moreo-ver reduces the adverse events occurrence in newborns.关键词
妊娠期糖尿病/益生菌/糖脂代谢/胰岛素受体底物1/葡萄糖转运蛋白4/囊泡相关蛋白23Key words
gestational diabetes mellitus/probiotics/glucolipid metabolism/insulin receptor substrate-1/glucose transporter 4/synaptosome-associated protein of 23 kDa分类
医药卫生引用本文复制引用
秦智娟,马宗丽,邹美林,朱晓琴,刘姝,王晓梅..益生菌联合饮食干预对妊娠期糖尿病糖脂代谢及妊娠结局的影响[J].重庆医学,2024,53(1):102-107,113,7.基金项目
江苏省南通市卫健委面上项目(MSZ2022079) （MSZ2022079）
江苏省南通市卫健委青年基金科研项目(QB2021033) （QB2021033）
江苏省如皋市科技攻关计划项目(RG2021SZD018). （RG2021SZD018）
