动物医学进展2024，Vol.45Issue(1)：60-66,7.
小鼠亚慢性伏马毒素B1中毒对血液生化指标的影响及组织病理变化的观察
Effects of Subchronic Fumonisin B1 Poisoning on Blood Biochemical Indexes and Observation of Histopathological Lesions in Mice
摘要
Abstract
In order to explore the effects of subchronic poisoning of fumonisin B1(FB1)in mice on blood bio-chemical indicators and histopathology,40 male Kunming mice were selected for the experiment,and a sub-chronic poisoning model of FB1 was established by adding feed.The control group(standard basic feed,C group)and fumonisin group(5 mg/kg FB1 mixed basic feed,FB1 group)were continuously fed for 42 d.Daily weighing,the organs of mice were weighed in the 21 d and 42 d of the experiment to calculate the or-gan ratio;blood biochemical indicators were measured;HE staining was used to observe the histopatho-logical lesions of liver and other 12 organs.The results showed that,compared with C group,in 21 d and 42 d,the coefficients of organs such as the liver in group FB1 decreased significantly;the content of serum ALT in group FB1 increased significantly,and the content of UA decreased significantly;blood routine in-dicators were significantly abnormal;histopathological results showed that there was certain pathological damage to liver and other 12 organs in FB1 group.It is suggested that 5 mg/kg FB1 infection can affect the blood biochemical indicators of mice and cause certain damage to various tissues and organs of mice.关键词
伏马毒素B1/亚慢性中毒/血液生化/组织损伤/小鼠Key words
fumonisin B1/poisoning/biochemistry/tissue damage/mouse分类
农业科技引用本文复制引用
李若彬,朱庆阁,黎晓雯,王凯,刘阳,曹嫦妤..小鼠亚慢性伏马毒素B1中毒对血液生化指标的影响及组织病理变化的观察[J].动物医学进展,2024,45(1):60-66,7.基金项目
国家重点研发计划(2022YFE0139500) （2022YFE0139500）
广东省基础与应用基础研究基金(2022B1515130003) （2022B1515130003）
