动物医学进展2024，Vol.45Issue(1)：83-88,6.
脱氢乙酸钠对不同性别Wistar大鼠凝血功能的影响
Effects of Sodium Dehydroacetate on Coagulation Function in Wistar Rats of Different Sex
摘要
Abstract
In order to explore the effects of sodium dehydroacetate(S-DHA)on the coagulation function of Wistar rats and the differences between sexes,four doses of 50,100,150 and 200 mg/kg were set,and each dose was divided into male and female groups.At the same time,the control group was set.The rats were administered continuously by oral gavage for 13 days.The prothrombin time(PT),activated partial throm-boplastin time(APTT),serum VK1 level and S-DHA concentration were detected on the 3rd,5th,7th,9th,11th and 13th days,respectively.The results showed that body weight,feed consumption and serum VK1 level were significantly decreased,and PT and APTT were prolonged.The concentration of serum S-DHA in female rats was significantly higher than that in male rats.The correlations of PT and APTT with serum S-DHA concentration and serum VK1 level in female rats were higher than those in male rats.S-DHA caused abnormal coagulation function in Wistar rats,and female rats were more susceptible to S-DHA than male rats.关键词
脱氢乙酸钠/Wistar大鼠/凝血异常/敏感性Key words
sodium dehydroacetate/Wistar rat/abnormal blood coagulation/sensibility分类
农业科技引用本文复制引用
毕思才,肖宜容,王存凯,张媛,江雅,陈新,张雨梅..脱氢乙酸钠对不同性别Wistar大鼠凝血功能的影响[J].动物医学进展,2024,45(1):83-88,6.基金项目
江苏省高等学校优势学科建设工程项目 （）
