大学化学2023，Vol.38Issue(12)：67-74,8.DOI:10.3866/PKU.DXHX202307023
格隆溴铵立体异构体杂质的毛细管电泳测定
Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis:Recommendation of a Pharmaceutical Analysis Experiment
摘要
Abstract
This article recommends a pharmaceutical analysis experiment"chiral capillary electrophoresis analysis of the stereoisomers of the drug Glycopyrrolate bromide".The experiment includes the selection of cyclodextrin chiral selector,optimization of capillary electrophoresis separation conditions,and construction of a standard curve.From the perspective of pharmaceutical analysis,this experiment focuses on introducing the principle of capillary electrophoresis analysis,the principle of chiral separation,and the importance of analyzing stereoisomeric impurities in drugs.It is suggested to be offered in majors such as applied chemistry,pharmacy,and pharmaceutical engineering.关键词
毛细管电泳/手性分析/格隆溴铵/环糊精/药物分析实验Key words
Capillary electrophoresis/Chiral analysis/Glycopyrrolate bromide/Cyclodextrin/Pharmaceutical analysis experiment分类
社会科学引用本文复制引用
李凤,孟然然,张含智,屈颖娟,康经武..格隆溴铵立体异构体杂质的毛细管电泳测定[J].大学化学,2023,38(12):67-74,8.基金项目
西安文理学院药物分析课程改革项目(JY2023KGC11) （JY2023KGC11）
西安文理学院仪器分析MOOC课程改革项目(JY2022KGA05) （JY2022KGA05）
国家自然科学基金(92053101,21175146) （92053101,21175146）
