大学化学2023，Vol.38Issue(12)：205-211,7.DOI:10.3866/PKU.DXHX202304067
甘氨酸催化下串联合成香豆素-3-羧酸
Tandem Synthesis of Coumarin-3-Carboxylic Acid Catalyzed by Glycine
摘要
Abstract
"Coumarin-3-carboxylic acid preparation"is a classic task-based teaching method used in basic organic chemistry experiments.During the experiment,we found that the synthesis of coumarin-3-carboxylic acid was complicated,time-consuming,consisted of several steps,and the reagents involved were not environmentally friendly.A modification was proposed to increase the effective use of teaching time,realize the greenness of the experimental process,and enhance the extensibility and exploration of the experiment.In an improved experiment,the tandem synthesis of coumarin-3-carboxylic acid was accomplished using Meldrum's acid and salicylaldehyde under reflux conditions in water as the solvent and glycine as the catalyst.Once the compound was prepared,its structure was characterized by melting point analysis,infrared spectroscopy,and nuclear magnetic resonance.The entire experiment lasted for approximately 4 h,which is suitable for teaching undergraduates.This improved experiment was based on green synthesis supplemented by physical characterization,which effectively increased the extensibility.We also explored online and offline mixed teaching models to effectively cultivate students'scientific exploration abilities.关键词
香豆素-3-羧酸/甘氨酸/水杨醛/丙二酸环(亚)异丙酯/绿色合成Key words
Coumarin-3-carboxylicacid/Glycine/Salicylaldehyde/2,2-Dimethyl-1,3-dioxane-4,6-dione/Green synthesis分类
社会科学引用本文复制引用
董军,陈友威,常伟,桑泽矾,曾子航,徐国栋..甘氨酸催化下串联合成香豆素-3-羧酸[J].大学化学,2023,38(12):205-211,7.基金项目
国家自然科学基金(51907173) （51907173）
江苏省高等学校基础科学(自然科学)研究面上项目(22KJB150046) （自然科学）
