大学化学2023，Vol.38Issue(12)：212-219,8.DOI:10.3866/PKU.DXHX202304094
智能型药物控释可视化系统的构建与表征
Construction and Characterization of Intelligent,Controlled Drug Release Visualization Systems:A New Design and Teaching Practice of Polymer Experiments
摘要
Abstract
This study presents a new experimental design and teaching practice for polymer chemistry,physical chemistry,and instrument analysis.Here,a type of thermosensitive polymer microgel was synthesized in an aqueous solution by free radical precipitation polymerization.The thermo-responsivity of these microgels was assessed using a UV-Vis spectrophotometer and dynamic light scattering instrument.These microgels were then utilized as carriers to construct a controlled drug delivery system,in which the drug was uploaded to the microgels in the swollen state and released from the microgels in the collapsed state.To understand the drug release process,a combination of color theory and chemical knowledge was proposed,in which the drug with visible range absorption was selected to"visualize"the drug release process,making it more intuitive and observable.Based on this perceptual understanding,the molecular diffusion mechanism of the drug release process was analyzed rationally.This experiment was based on cutting-edge green research results that have been widely investigated and verified.Moreover,this experiment,which can be extended to other responsive polymers and drugs,has universal applicability.This experiment can not only exercise basic operational ability but also help develop research skills for identifying and solving problems and improve students'innovation ability.关键词
温敏性微凝胶/自由基沉淀聚合/药物控释系统/可视化检测/实验教学Key words
Thermo-sensitive microgels/Free radical precipitation polymerization/Controlled drug release system/Visual detection/Experimental teaching分类
社会科学引用本文复制引用
张来英,苟洪瑀,庄海妮,秦宇航,邱惠娟,吴伟泰..智能型药物控释可视化系统的构建与表征[J].大学化学,2023,38(12):212-219,8.基金项目
2021年度教育部"基础学科拔尖学生培养计划2.0"研究课题 （）
国家自然科学基金(21574107,21774105) （21574107,21774105）
2020年度福建省"雏鹰计划"青年拔尖人才支持项目 （）
