大学化学2023，Vol.38Issue(12)：228-234,7.DOI:10.3866/PKU.DXHX202304081
"乙酰水杨酸的制备和分析表征"教学实验的优化和改进
Optimization and Improvement of the Teaching Experiment of"Synthesis,Analysis and Characterization of Acetylsalicylic Acid"
摘要
Abstract
Using salicylic acid and acetic anhydride as raw materials,silica gel as a catalyst,and microwave technology as an optimization method,the university organic chemistry teaching experiment of'Preparation and Characterization of Acetylsalicylic Acid'was improved.Through the experiment,the impact of factors such as microwave power,reaction time,and raw material ratio on the final yield was explored.The optimal experimental conditions were determined as follows:silica gel with a particle size of 100-200 mesh,0.25 g in quantity,60 s reaction time,70 ℃ reaction temperature,500 W microwave power,and a molar ratio of acetic anhydride to salicylic acid of 2:1.The average yield was approximately 68.0％.Compared to the conventional heating method for the preparation of acetylsalicylic acid,microwave-assisted synthesis offers advantages such as simplicity,shorter reaction time,higher product yield,fewer impurities,and environmental friendliness.Introducing this microwave experiment into undergraduate organic chemistry laboratory teaching can broaden students'horizons,enrich experimental teaching content,and further improve the teaching level.关键词
微波/硅胶/乙酰水杨酸/绿色化学Key words
Microwave/Silica gel/Acetylsalicylic acid/Green chemistry分类
社会科学引用本文复制引用
乔佳凡,刘刚,丁姝,吴书涵,孙继超,马莹,张恒,贾春江,徐政虎,苑世领.."乙酰水杨酸的制备和分析表征"教学实验的优化和改进[J].大学化学,2023,38(12):228-234,7.基金项目
教育部首批新文科研究与改革实践项目(2021100060) （2021100060）
山东省本科教学改革研究项目(M2021336,Z2021039) （M2021336,Z2021039）
山东大学青年交叉科学群体项目(2020QNQT018) （2020QNQT018）
山东大学教育教学改革研究项目(2022Y070,2022Y073,2022Z64,2021S09,2021Y232,2019P02) （2022Y070,2022Y073,2022Z64,2021S09,2021Y232,2019P02）
山东大学实验室建设与管理研究项目(sy20221201,sy20212202) （sy20221201,sy20212202）
山东省研究生教育优质课程建设项目(SDYKC21014,YZKC202107) （SDYKC21014,YZKC202107）
