分子影像学杂志2024，Vol.47Issue(1)：1-6,6.DOI:10.12122/j.issn.1674-4500.2024.01.01
18F-PSMA-1007 PET/CT显像可无创精准诊断前列腺癌并确定分期
18F-PSMA-1007 PET/CT examination can noninvasively diagnose and stage the vast majority of prostate cancer
摘要
Abstract
Objective To investigate the application value of PET/CT imaging technology based on 18F-PSMA-1007 in the non-invasive and accurate diagnosis of prostate cancer(PCa).Methods A total of 117 patients with suspected PCa admitted to Meizhou People's Hospital from November 2020 to April 2022 were examined by 18F-PSMA-1007 PET/CT before biopsy.The maximum standardized uptake value of the lesion and liver was measured by delineating the region of interest,and the tumor background ratio(TBR)was calculated with the liver as the background.Combined with the pathological results after biopsy(64 cases of PCa and 53 cases of benign),the TBR differences between benign and malignant diseases were compared,and the ROC curve was drawn to evaluate their diagnostic efficacy,so as to obtain the best cutoff value.Results The TBR level of PCa patients was higher than that of benign patients,and there was significant difference between the two groups(P<0.001).The ROC curve was plotted by TBR to diagnose PCa,and the area under the ROC curve was 0.881(P<0.001),and the sensitivity and specificity were 78.1%and 94.3%,respectively,when the cutoff value was taken as 0.955.Moreover,among the 14 PCa patients with TBR below the cutoff value,7 had developed lymph nodes and/or bone metastases,which could be indirectly diagnosed as PCa.Conclusion 18F-PSMA-1007 PET/CT TBR has a high application value in distinguishing benign and malignant prostate lesions.Using TBR=0.955 as the cut-off value can achieve good diagnostic efficiency.Even if the TBR is lower than the cutoff value,the detection of metastases can be used as a supplementary diagnosis of PCa and further improve the diagnostic accuracy.18F-PSMA-1007 PET/CT examination can noninvasively diagnose and stage the vast majority of PCa.关键词
18F-PSMA-1007/PET/CT/前列腺癌/无创性诊断Key words
18F-PSMA-1007/PET/CT/prostate cancer/noninvasive diagnosis引用本文复制引用
章明,马晓芬,楼云龙,陈丹丹..18F-PSMA-1007 PET/CT显像可无创精准诊断前列腺癌并确定分期[J].分子影像学杂志,2024,47(1):1-6,6.基金项目
国家自然科学基金(82001792) Supported by the National Natural Science Foundation of China(82001792) （82001792）
