分子影像学杂志2024，Vol.47Issue(1)：36-41,6.DOI:10.12122/j.issn.1674-4500.2024.01.07
多参数磁共振影像组学列线图在术前可有效预测直肠癌淋巴血管浸润
Multi-parametric magnetic resonance imaging radiomics nomogram can effectively predict lymphovascular invasion in rectal cancer before surgery
摘要
Abstract
Objective To explore the value of a nomogram model based on multi-parametric MRI radiomics combined with clinical risk factors in preoperative prediction of lymphovascular invasion of rectal cancer.Methods A total of 112 patients who underwent preoperative multi-parametric MRI examination and were confirmed as rectal adenocarcinomas by postoperative pathology in the First Affiliated Hospital of Bengbu Medical College were retrospectively analyzed.The clinical and pelvic imaging data of the patients were collected,and they were randomly divided into training set and validation set at a ratio of 7:3.Clinical independent risk factors related to lymphovascular invasion in rectal cancer were selected through single-multiple Logistic regression analysis.Regions of interest were manually delineated on T2WI,diffusion weighted imaging and T1WI enhanced sequences,and radiomics characteristics were extracted.The optimal radiomics characteristics were selected through characteristics dimension reduction,and a radiomics model was constructed.A nomogram model was built by combining clinical predictive factors with radiomics score labels.The predictive efficiency of the model was evaluated adopting area under the ROC curve,calibration curve and decision curve analysis.Results The nomogram model showed excellent predictive efficiency,with an area under the curve of 0.876(95%CI:0.799-0.952)and 0.769(95%CI:0.600-0.938)for the training set and validation set respectively,which was significantly higher than the radiomics model(0.818,0.741)and clinical model(0.714,0.548).Conclusion The nomogram model exhibited excellent predictive efficiency in predicting lymphovascular invasion of rectal cancer,which can provide important guidance for clinical decision-making preoperatively.关键词
直肠癌/淋巴血管浸润/影像组学/磁共振成像/列线图模型Key words
rectal cancer/lymphovascular invasion/radiomics/magnetic resonance imaging/nomogram model引用本文复制引用
王月燕,赵以惠,陈艾琪,杜小萌,钱宝鑫,潘成武,马宜传..多参数磁共振影像组学列线图在术前可有效预测直肠癌淋巴血管浸润[J].分子影像学杂志,2024,47(1):36-41,6.基金项目
蚌埠医学院自然科学重点项目(BYKY2019025ZD) （BYKY2019025ZD）
