国际老年医学杂志2024，Vol.45Issue(1)：6-10,5.DOI:10.3969/j.issn.1674-7593.2024.01.002
慢性阻塞性肺疾病稳定期炎症生物标志物与肺功能的相关性
The Correlation between Inflammatory Biomarkers and Lung Function in COPD Stable Phase
摘要
Abstract
Objective To investigate the correlation between interleukin(IL)-1 family,classical inflammatory markers and pulmonary function in patients with stable chronic obstructive pulmonary disease(COPD).Methods Forty-five patients with stable COPD who visited the outpatient clinic or ward of the Department of Geriatrics,Beijing Jishuitan Hospital,Capital Medical Uni-versity,from July 2021 to December 2022 were selected for a prospective cross-sectional survey to collect gender,age,smoking his-tory and smoking index,underlying disease information,and serum IL-1 family(IL-1α,IL-1β,IL-18),IL-6,IL-8,TNF-α detection and pulmonary function tests.Results Multivariate regression analysis found that IL-18 was independently corre-lated with forced expiratory volume in the first second(FEV1)predicted value(FEV1％),IL-18 and age were independently asso-ciated with the single-breath diffusing lung capacity of carbon monoxide(DLCO),IL-18 was independently related to the improve-ment rate of FEV1.Conclusion IL-18 level in stable COPD was significantly correlated with pulmonary ventilation function,pul-monary diffusion capacity and FEV1 improvement rate,which suggesting that IL-18 may play an important role in the development of the disease at this stage and can be used as the good monitoring indicators for the evaluation of stable COPD.关键词
慢性阻塞性肺疾病/稳定期/白细胞介素-1家族/炎症因子/肺功能Key words
Chronic obstructive pulmonary disease/Stable phase/IL-1 family/Inflammatory factors/Pulmonary func-tion引用本文复制引用
原源,邓晓慧,岳睿,葛晓竹,汪薇,田巍..慢性阻塞性肺疾病稳定期炎症生物标志物与肺功能的相关性[J].国际老年医学杂志,2024,45(1):6-10,5.基金项目
北京市属医院科研培育项目(PZ2021004) （PZ2021004）
