国际老年医学杂志2024，Vol.45Issue(1)：18-22,5.DOI:10.3969/j.issn.1674-7593.2024.01.004
血清白细胞介素-17、降钙素原对伴肺部感染的老年重症慢性阻塞性肺疾病患者预后的预测
Prognosis Value of Serum Interleukin-17 and Procalcitonin in Elderly Patients with Severe Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection
摘要
Abstract
Objective To observe the expression of serum interleukin(IL)-17 and procalcitonin(PCT)in elderly pa-tients with severe chronic obstructive pulmonary disease(COPD)accompanied by pulmonary infection,and to explore their predictive value for the prognosis of patients.Methods A total of 120 elderly patients with severe COPD complicated with pulmonary infection admitted to Beijing Rehabilitation Hospital Affiliated with Capital Medical University from March 2021 to May 2022 were selected as the study subjects.All patients were followed up for 6 months.Serum IL-17 and PCT levels were measured,general data were collect-ed,and the above data were statistically analyzed.Results At the end of follow-up,80 patients survived with a survival rate of 66.67％and 40 patients died with a mortality rate of 33.33％.There was no significant difference in gender,age,combined under-lying diseases,smoking history and other data between the death group and the survival group(P＞0.05);the serum IL-17 and PCT levels in the death group were higher than those in the survival group,and the duration of COPD and pulmonary infection was lon-ger than those in the survival group,and the differences were statistically significant(P＜0.05).IL-17,PCT,duration of COPD and duration of pulmonary infection were used as independent variables,and the prognosis of patients was used as dependent variable,multivariate logistic regression analysis was performed.The results showed that serum IL-17 and PCT levels were independent risk factors for death in elderly patients with severe COPD and pulmonary infection(P＜0.05).ROC curves showed that the area under the curve of serum IL-17 and PCT for predicting death in elderly patients with severe COPD and pulmonary infection was＞0.90.Conclusion Serum IL-17 and PCT levels are associated with prognosis in elderly patients with severe COPD with pulmonary infec-tion and may be risk factors for increased risk of death.关键词
慢性阻塞性肺疾病/老年人/白细胞介素-17/降钙素原/预后Key words
Chronic obstructive pulmonary disease/Elderly/Interleukin-17/Calcitoninogen/Prognosis引用本文复制引用
刘自双,杜歌,陈珊珊,张新峰,刘芳芳,芮曦..血清白细胞介素-17、降钙素原对伴肺部感染的老年重症慢性阻塞性肺疾病患者预后的预测[J].国际老年医学杂志,2024,45(1):18-22,5.基金项目
首都医科大学附属北京康复医院2020-2022年科技发展专项立项任务(2020-005) （2020-005）
