国际老年医学杂志2024，Vol.45Issue(1)：76-81,6.DOI:10.3969/j.issn.1674-7593.2024.01.014
终末期肝病模型评分联合降钙素原在乙型肝炎病毒相关慢加急性肝衰竭发生急性肾损伤的预测作用
Predictive Effect of Model for End-stage Liver Disease Score Combined with Procalcitonin on Acute Kidney Injury in Hepatitis B Virus-related Acute-on-chronic Liver Failure
摘要
Abstract
Objective To investigate the predictive value of the model for end-stage liver disease(MELD)score com-bined with procalcitonin(PCT)for acute kidney injury in patients with hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).Methods A retrospective analysis of 216 HBV-AC L F patients hospitalized in the First Affiliated Hospital of Har-bin Medical University from January 2019 to December 2022 was performed.According to whether acute kidney injury occurred during hospitalization,they were divided into an acute kidney injury group(51 cases)and a non acute kidney injury group(165 cases).The clinical data of the patients was collected,A multivariate logistic regression model was used to screen the influencing factors of a-cute kidney injury in HBV-ACLF patients,and the ROC curve was used to evaluate the predictive value of MELD score combined with PCT for the occurrence of acute kidney injury in HBV-ACLF patients.Results Univariate analysis showed that there were sig-nificant differences in age,albumin,prothrombin time,PCT,acute physiology and chronic health evaluation H(APACHE Ⅱ),and MELD scores between the two groups(P＜0.05).The results of multivariate logistic regression analysis showed that PCT,A-PACHE Ⅱ score,and MELD score were independent risk factors for acute kidney injury during hospitalization in HBV-ACLF pa-tients(P＜0.05).ROC curve showed that MELD score combined with PCT predicted the area under the curve of acute kidney injury during hospitalization in HBV-ACLF patients higher than MELD score and PCT single index.Conclusion Elevated MELD score and PCT are independent risk factors for AKI complicating HBV-ACLF,and the combined use can predict the risk of acute kidney injury during hospitalization to assist clinical management of patients.关键词
慢加急性肝衰竭/急性肾损伤/终末期肝病模型/炎症Key words
Acute-on-chronic liver failure/Acute kidney injury/Model for end-stage liver disease/Inflammation引用本文复制引用
王春旭,王林,王洪岩..终末期肝病模型评分联合降钙素原在乙型肝炎病毒相关慢加急性肝衰竭发生急性肾损伤的预测作用[J].国际老年医学杂志,2024,45(1):76-81,6.基金项目
黑龙江省自然科学基金(Y2019Q06) （Y2019Q06）
