国际医学放射学杂志2024，Vol.47Issue(1)：7-11,59,6.DOI:10.19300/j.2024.L20973
基于伪连续式动脉自旋标记对原发性三叉神经痛病人疼痛相关脑区血流量的分析
Cerebral blood flow analysis of pain-related brain regions in patients with primary trigeminal neuralgia using pseudo continuous arterial spin labeling
摘要
Abstract
Objective To analyze the changes of regional cerebral blood flow(rCBF)in pain-related brain regions of patients with primary trigeminal neuralgia(PTN)by pseudo continuous arterial spin labeling(pCASL)technique.Methods Forty-eight patients with PTN were retrospectively analyzed and divided into right PTN(RPTN)group(28 cases)and left PTN(LPTN)group(20 cases)according to the pain site,and 35 healthy control group(HC)cases were included.All subjects underwent conventional head MRI and arterial spin labeling(ASL)examination.Five pain-related brain regions of interest(ROI)including posterior central gyrus,insula,anterior cingulate gyrus,orbitofrontal cortex,and thalamus were selected for rCBF values analysis.Paired t test was used to compare rCBF values of left and right sides of the three groups,SNK corrected one-way ANOVA analysis was used to compare rCBF values among the three groups.Results The rCBF increased in both the left posterior central gyrus and orbitofrontal cortex of the RPTN group,and similarly in the right posterior central gyrus and orbitofrontal cortex of the LPTN group(both P<0.05).Additionally,both the RPTN and LPTN groups exhibited an increase in rCBF in the right insular(both P<0.05).Conversely,the rCBF decreased in both the left thalamus of the RPTN group and the right thalamus of the LPTN group(both P<0.05).Comparisons among the three groups revealed that the rCBF values of the left posterior central gyrus and orbitofrontal cortex in the RPTN group,as well as the right posterior central gyrus and orbitofrontal cortex in the LPTN group,were higher than those in the other two groups(both P<0.05).Furthermore,the rCBF values of the left thalamus in the RPTN group and the right thalamus in the LPTN group were lower than those of the other two groups(both P<0.05).Additionally,the rCBF values of the right insula in both RPTN and LPTN groups were higher than those in the HC group(both P<0.05).Conclusion Using pCASL technology,alterations in the rCBF of the postcentral gyrus,right insula,orbitofrontal cortex,and thalamus were observed in patients with PTN,indicating that the occurrence of PTN may impact cerebral blood flow in pain-related brain regions.关键词
三叉神经痛/磁共振成像/伪连续式动脉自旋标记/疼痛相关脑区/局部脑血流量Key words
Trigeminal neuralgia/Magnetic resonance imaging/Pseudo continuous arterial spin labeling/Pain-related brain regions/Regional cerebral blood flow分类
医药卫生引用本文复制引用
程乾胜,韩彤,曹宸,韩碧辉,程悦,倪红艳..基于伪连续式动脉自旋标记对原发性三叉神经痛病人疼痛相关脑区血流量的分析[J].国际医学放射学杂志,2024,47(1):7-11,59,6.基金项目
天津市科技计划项目(21JCZDJC01210,21JCYBJC01290) （21JCZDJC01210,21JCYBJC01290）
天津市自然科学基金(21JCYBJC01290) （21JCYBJC01290）
天津市卫生健康科技重点学科专项(TJWJ2023XK012) （TJWJ2023XK012）
