广西医学2023，Vol.45Issue(20)：2430-2435,6.DOI:10.11675/j.issn.0253-4304.2023.20.02
强直性脊柱炎患者血清Caspase-1和PTX3的表达水平及其临床意义
Expressions of serum Caspase-1,PTX3 in patients with ankylosing spondylitis and their clinical significance
摘要
Abstract
Objective To explore the expressions of serum Caspase-1 and pentraxin 3(PTX3)in patients with ankylosing spondylitis and their clinical significance.Methods A total of 83 patients with ankylosing spondylitis(the case group),and 60 healthy check-up individuals(the control group)were selected as the research subjects.The serum Caspase-1,PTX3,interleukin(IL)-17,IL-23,and tumor necrosis factor α(TNF-α)levels of both groups were detected by using the ELISA.The serum C-reactive protein(CRP)level of both groups was detected by employing the immunoturbidimetry.Patients in the case group were evaluated by the Bath Ankylosing Spondylitis Disease Activity Index(BASDAI),modified Stoke Ankylosing Spondylitis Spine Score(mSASSS),and patients of the case group were divided into disease stable group(n=39)or disease active group(n=44)according to BASDAI score.The correlation of serum Caspase-1 and PTX3 levels with disease activity and inflammatory indexes was analyzed by using the Pearson correlation or Spearman rank correlation.The diagnostic value of serum Caspase-1,PTX3 levels for ankylosing spondylitis was evaluated by drawing the receiver operating characteristic(ROC)curve.Results The levels of serum Caspase-1,PTX3,CRP,IL-17,IL-23,and TNF-α were higher in the case group than in the control group(P＜0.05).The levels of serum Caspase-1,PTX3,and BASDAI score,mSASSS were higher in the disease active group than in the disease stable group(P＜0.05).The levels of serum Caspase-1,PTX3 levels positively correlated with BASDAI score,mSASSS,and serum CRP,IL-17,IL-23 and TNF-α levels in the case group(P＜0.05).The results of ROC curve revealed that areas under the curve of serum Caspase-1 and PTX3 levels for diagnosing ankylosing spondylitis were 0.793 and 0.772,respectively,area under the curve of the combined diagnosis of the two was 0.875,and the efficiency of combined diagnosis was superior to single index(P＜0.05).Conclusion Serum Caspase-1 and PTX3 levels in patients with ankylosing spondylitis are elevated,and they are related to disease activity and expressions of inflammatory factors.Both of the two can be regarded as adjuvant diagnosis for ankylosing spondylitis,and the combined detection exerts higher diagnostic efficiency.关键词
强直性脊柱炎/Caspase-1/正五聚蛋白3/疾病活动度/诊断效能Key words
Ankylosing spondylitis/Caspase-1/Pentraxin 3/Disease activity/Diagnostic efficiency分类
医药卫生引用本文复制引用
马芹,李晓军,李静..强直性脊柱炎患者血清Caspase-1和PTX3的表达水平及其临床意义[J].广西医学,2023,45(20):2430-2435,6.基金项目
安徽省卫生健康委员会科研项目(2019QK020) （2019QK020）
