广西医学2023，Vol.45Issue(20)：2452-2455,4.DOI:10.11675/j.issn.0253-4304.2023.20.06
抗VEGF药物治疗湿性老年性黄斑变性患者的远期预后及其影响因素
Long-term prognosis of anti-VEGF drug for the treatment of patients with wet age-related macular degeneration and its influencing factors
摘要
Abstract
Objective To explore the long-term prognosis of anti-vascular endothelial growth factor(VEGF)drug for the treatment of patients with wet age-related macular degeneration(wAMD)and its influencing factors.Methods The clinical data of 56 patients(65 eyes)with wAMD who received intravitreal injection of anti-VEGF drug(conbercept)were retrospectively analyzed.All patients were followed up for 2 years,according to the improvement of naked eye visual acuity in patients,patients were divided into effective group or ineffective group.The clinical data were compared between patients of the two groups.The factors affecting patients'long-term visual acuity were analyzed by the multivariate Logistic regression model.Results Among 56 wAMD patients(65 eyes),the visual acuity of 32 cases(34 eyes)of patients(57.14％)was improved as compared with before treatment.There were statistically significant differences in disease course,the Self-Rating Scale of Sleep(SRSS)score after 1 day of treatment,and proportions of concomitant hypertension,concomitant coronary heart disease,as well as smoking history between the two groups(P＜0.05).The results of multivariate Logistic regression analysis revealed that disease course,SRSS score after 1 day of treatment,and concomitant hypertension were the influencing factors for long-term visual acuity of wAMD patients after anti-VEGF drug therapy(P＜0.05).Conclusion Anti-VEGF drug therapy can ameliorate long-term visual acuity of wAMD patients to a certain extent.Disease course,SRSS score after 1 day of treatment,and concomitant hypertension are the influencing factors for long-term visual acuity of wAMD patients after anti-VEGF drug therapy.关键词
湿性老年性黄斑变性/血管内皮生长因子/视力/远期疗效/影响因素Key words
Wet age-related macular degeneration/Vascular endothelial growth factor/Visual acuity/Long-term efficacy/Influencing factors分类
医药卫生引用本文复制引用
罗海燕,文美丹,陶苗苗,刘琼,陶玲..抗VEGF药物治疗湿性老年性黄斑变性患者的远期预后及其影响因素[J].广西医学,2023,45(20):2452-2455,4.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190734、Z20201408) （Z20190734、Z20201408）
