摘要
Abstract
Objective To explore the clinical effect of Qijing Dihuang Decoction combined with valsartan for the treatment of patients with diabetic nephropathy(DN)with yin and yang deficiency in G2A2 stage.Methods A total of 72 DN patients with yin and yang deficiency in G2A2 stage were randomly divided into control group or observation group,with 36 cases in each group.On the basis of routine treatment,the control group was treated with valsartan,while the observation group received Qijing Dihuang Decoction combined with valsartan for treatment.The pre-and 12-week post-treatment Traditional Chinese Medicine syndromes score,renal function indices(urinary albumin-to-creatinine ratio[UACR],estimated glomerular filtration rate[eGFR]),blood lipid levels(total cholesterol,triglyceride,LDL-C,HDL-C),and indices related to blood glucose control(fasting blood glucose,2-hour postprandial blood glucose,HbA1c),blood pressure,as well as clinical efficacy of Traditional Chinese Medicine after treatment,the incidence rate of adverse reactions during treatment were compared between patients of the two groups.Results After treatment,the Traditional Chinese Medicine syndromes score,UACR,and serum levels of total cholesterol,triglyceride,LDL-C of the two groups were decreased as compared with before treatment,whereas eGFR of the two groups was elevated as compared with before treatment,and the observation group exhibited superior aforesaid indices to compare with the control group(P＜0.05);furthermore,the levels of fasting blood glucose,2-hour postprandial blood glucose,HbA1 c,and blood pressure of the two groups were decreased as compared with before treatment,whereas serum HDL-C level of the two groups was elevated as compared with before treatment(P＜0.05);however,there was no statistically significant difference in indices as above between the two groups(P＞0.05).The observation group yielded a higher total clinical effective rate of Traditional Chinese Medicine as compared with the control group(91.7％vs.69.4％,P＜0.05).No statistically significant difference in the incidence rate of adverse reactions during treatment was found between patients of the two groups(P＞0.05).Conclusion Compared with application of valsartan alone,employing Qijing Dihuang Decoction combined with valsartan based on routine treatment can preferably ameliorate clinical symptoms and renal function of DN patients with yin and yang deficiency in G2A2 stage,regulate blood lipid level,exerting a favorable safety.关键词
糖尿病肾病/阴阳两虚证/芪精地黄汤/缬沙坦/临床效果Key words
Diabetic nephropathy/Yin and yang deficiency syndrome/Qijing Dihuang Decoction/Valsartan/Clinical effect分类
医药卫生
