广州医药2024，Vol.55Issue(1)：18-24,7.DOI:10.3969/j.issn.1000-8535.2024.01.003
LINC02038与子宫内膜癌发生、发展的关联性分析
Association analysis of LINC02038 with endometrial carcinoma progression
摘要
Abstract
Objective To analyze the expression of long non-coding RNA LINC02038 and its relationship with the occurrence and development of endometrial carcinoma(EC),explore its potential biological mechanisms,and provide potential biomarkers for targeted therapy of EC.Methods Quantitative real-time PCR was used to detect the expression levels of LINC02038 in 42 EC tissues and their adjacent tissues.The LINC02038 overexpressin vector was constructed and transfected into EC Ishikawa cells.CCK-8,Transwell migration and invasion assays were performed to examine the effects of LINC02038 overexpression on cancer cell proliferation,migration and invasion.Public TCGA data were analyzed to investigate the associations between LINC02038 and EC pathogenesis and prognosis.GO,KEGG and GSEA enrichment analyses were conducted to elucidate the potential biological mechanisms of LINC02038.Results LINC02038 expression was significantly upregulated in EC tissues compared to adjacent non-tumor tissues(P＜0.001).Overexpression of LINC02038 markedly promoted the proliferation and migration of Ishikawa cells.Bioinformatics analysis suggested that LINC02038 may participate in regulating cell differentiation,hormone secretion,extracellular matrix remodeling and other processes,as well as activating NF-κB,extracellular matrix receptor and other signaling pathways involved in endometrial carcinogenesis.Conclusions The aberrant expression of LINC02038 is associated with EC occurrence and may serve as a potential biomarker for assessing the risk of this cancer.关键词
子宫内膜癌/长链非编码RNA/LINC02038Key words
endometrial carcinoma/long non-coding RNA/LINC02038引用本文复制引用
赵二勇,陈悦霖,易莉莎,林佩萱..LINC02038与子宫内膜癌发生、发展的关联性分析[J].广州医药,2024,55(1):18-24,7.基金项目
广州市科技计划项目(2023A03J0870) （2023A03J0870）
