摘要
Abstract
Objective To investigate the value of five testing techniques in the clinical diagnosis of pneumoconiosis com-bined pulmonary tuberculosis,including sputum smear,Xpert Mycobacterium tuberculosis/rifampicin(Xpert MTB/RIF),identifi-cation of Mycobacterium species,sputum acid-fast bacilli culture and tuberculosis-interferon-gamma release assays(TB-IGRA).Methods Patients with pneumoconiosis combined with tuberculosis who were hospitalized in the First Hospital of Xiamen University from July 2016 to May 2021 were included in the study.The patients were divided into the pneumoconiosis group(156 cases)and pneumoconiosis combined with tuberculosis group(111 cases)according to whether the pneumoconiosis patients were combined with tuberculosis or not.The general data of the patients in the two groups were compared with respect to gender,age,and dust exposure time,and the results of sputum smears,Xpert MTB/RIF,identification of Mycobacterium species,sputum acid-fast bacilli culture and TB-IGRA were collected to analyze the differences and the diagnostic value in the five testing techniques of the positivity rates for patients who have pneumoconiosis combined with pulmonary tuberculosis.Results In the group with pneumoconiosis combined with tuberculosis,the positive detection rate of TB-IGRA was the highest(81.1%),which was higher than other 4 testing methods(P＜0.01).Combined testing in pairs suggested that the testing method of Xpert MTB/RIF and TB-IGRA combination was the highest(96.4%),significantly higher than the other 9 combinations(P＜0.01).Conclusions TB-IGRA has higher positive detection rate for patients with pneumoconiosis combined with tuberculosis,and diagnostic efficiency can be further improved by combining Xpert MTB/RIF assay testing,which is of great clinical diagnostic value for the early diagnosis of pneumoconiosis combined with tu-berculosis.关键词
尘肺/肺结核/Xpert MTB/RIF/TB-IGRA/分枝杆菌菌种鉴定Key words
pneumoconiosis/pulmonary tuberculosis/Xpert MTB/RIF/TB-IGRA/identification of Mycobacterium species
