海南医学院学报2024，Vol.30Issue(2)：100-105,6.DOI:10.13210/j.cnki.jhmu.20231031.003
早发型与晚发型视神经脊髓炎谱系疾病患者的临床特点分析
Clinical characteristics of patients with early-and late-onset optic neuromyelitis optica spectrum disease
摘要
Abstract
Objective:To analyze the different clinical features of patients with early-onset(EO-NMOSDs)and late-onset neuromyelitis optica spectrum diseases(LO-NMOSDs).Methods:A total of 51 patients with neuromyelitis optica spectrum dis-ease who were diagnosed in our hospital for the first time from January 2015 to December 2022 were included in the First Affiliated Hospital of Hainan Medical College and divided into 22 cases in the EO-NMOSDs group and 29 cases in the LO-NMOSDs group according to whether the age of onset was≥50 years old.The basic data,Extended Disability Status Scale(EDSS)score,blood and cerebrospinal fluid test indicators of the two groups were statistically analyzed.Results:There were no significant differences in demographic characteristics,clinical features and serum AQP-4 antibody positivity rate between the two groups(all P>0.05),and there were significant differences in triglycerides(TG),low-density lipoprotein(LDL),apolipoprotein A(APOA),apolipo-protein B(APOB)and lipoprotein a(P=0.010,P=0.048,P=0.014,P=0.061,P=0.001,respectively),and cerebrospinal fluid LDH.There were significant differences between microprotein quantification and EDSS score(P=0.018,P=0.034,P=0.025,respectively),and the level of microprotein quantification in cerebrospinal fluid of LO-NMOSDs had a certain correlation with the degree of disability(r=0.52,P<0.03).Conclusion:LO-NMOSDs and EO-NMOSDs group patients have similar demo-graphic characteristics,serum AQP-4 antibody positive rate and clinical features,but compared with EO-NMOSDs,patients in LO-NMOSDs group are prone to abnormal lipid metabolism,higher trace proteins in cerebrospinal fluid and more likely to be dis-abled,and among LO-NMOSDs,the higher the trace protein in the cerebrospinal fluid,the more severe the disability status of pa-tients.关键词
视神经脊髓炎谱系疾病/晚发型/脑脊液微蛋白定量/EDSS评分Key words
Optic neuromyelitis optica spectrum disorders/Late onset/Cerebrospinal fluid microprotein quantification/EDSS score分类
医药卫生引用本文复制引用
栗菲,刘婷,杨逸昊,林慧霞,童婧怡,黎宗军,梁斌基,李其富..早发型与晚发型视神经脊髓炎谱系疾病患者的临床特点分析[J].海南医学院学报,2024,30(2):100-105,6.基金项目
Hainan Clinical Medicine Center Construction Project(2021)and Hainan Provincial Excellent Talent Team(QRCBT202121) （2021）
Key R&D Plan of Hainan Province(ZDYF2022SHFZ109) 海南省临床医学中心建设项目(2021)和海南省优秀人才团队(QRCBT202121) （ZDYF2022SHFZ109）
海南省重点研发计划(ZDYF2022SHFZ109) （ZDYF2022SHFZ109）
