海南医学院学报2024，Vol.30Issue(2)：106-112,7.DOI:10.13210/j.cnki.jhmu.20230927.004
阿司匹林抗血小板相关基因多态性在汉族NSTEMI患者人群中的分布
Distribution of gene polymorphisms associated with aspirin antiplatelet in the Han NSTEMI population
摘要
Abstract
Objective:To analyze the genotype and allele distribution characteristics of GPⅢa PLA2(rs5918),PEAR1(rs12041331),and PTGS1(rs10306114)genes related to the antiplatelet pharmacological effects of aspirin,providing reference for individualized treatment of Chinese Han NSTEMI patients.Methods:A total of 107 Han patients with NSTEMI in Beijing Luhe Hospital affiliated to Capital Medical University from January 2016 to December 2022 were selected as the research subjects.The genotypes of GPⅢa PLA2(rs5918),PEAR1(rs12041331)and PTGS1(rs10306114)were detected by fluorescence stain-ing in situ hybridization.The frequency distribution and allele distribution of genotype were analyzed.The results were analyzed whether there were statistical differences in the distribution of related alleles between the Han NSTEMI population and some popu-lations in the 1000 Genomes database.Results:In the Han NSTEMI population,the genotype frequencies of GPⅢa PLA2(rs5918)locus were TT 97.20%,TC 2.80%and CC 0%,the allele frequencies were T 98.60%and C 1.40%.The genotype frequencies of PEAR1(rs12041331)locus were GG 42.06%,GA 44.86%and AA 13.08%,the allele frequencies were G 64.49%and A 35.51%.The genotypes at the PTGS1(rs10306114)locus were all AA(100%),no AG or GG genotype was found.Conclusion:In the NSTEMI population of Han ethnic group,the mutation at GPⅢa PLA2(rs5918)site related to aspirin antiplatelet pharmacology is rare,and there is no mutation at PTGS1(rs10306114)site.Wild homozygotes are dominant in these two gene loci,while mutations in PEAR1(rs12041331)are more common.Some of the findings in this study are similar to those in previous reports or other populations included in the relevant database;however,some results differ from previous reports or other populations.关键词
阿司匹林/抗血小板/非ST段抬高型心肌梗死/基因多态性/基因型分布Key words
Aspirin/Antiplatelet/Non-ST-segment elevation myocardial infarction/Gene polymorphism/Genotype dis-tribution分类
医药卫生引用本文复制引用
李六水,王飞,周澳,杨青,刘宪军..阿司匹林抗血小板相关基因多态性在汉族NSTEMI患者人群中的分布[J].海南医学院学报,2024,30(2):106-112,7.基金项目
This study was supported by Capital Clinical Characteristic Application Research Project(Z181100001718144) （Z181100001718144）
Beijing Tongzhou District Science and Technology Plan Project(KJ2017CX036-06) （KJ2017CX036-06）
In-hospital Project of Shanghai Jinshan District Integrated Traditional Chinese and Western Medicine Hospital(2022-1) 首都临床特色应用研究项目(Z181100001718144) （2022-1）
北京市通州区科技计划项目(KJ2017CX036-06) （KJ2017CX036-06）
上海市金山区中西医结合医院院内课题(2022-1) （2022-1）
