海南医学院学报2024，Vol.30Issue(2)：139-147,9.DOI:10.13210/j.cnki.jhmu.20230510.001
微小RNA与炎症性肠病及其相关机制的研究进展
Advances in microRNA and inflammatory bowel disease and their related mechanisms
摘要
Abstract
Inflammatory bowel disease(IBD)is a complex and multifactorial disease characterized by chronic inflamma-tion of the gastrointestinal tract,mainly manifested by the accumulation of immune cells and pro-inflammatory cytokines in the intestinal mucosa.It is a kind of immune digestive system disease with high incidence in humans,and can be divided into ulcer-ative colitis(UC)and Crohn's disease(CD).The pathogenesis of IBD is complex,and numerous studies have shown that ge-netic,environmental,microbial,immune,autophagy and other factors may be involved in the pathogenesis of IBD.microR-NAs(miRNAs)play an important role in the pathophysiology of IBD.Studies have confirmed that miRNA plays an important role in the targeted regulation of intestinal barrier homeostasis,immune response and intestinal epithelial autophagy.MiRNA have not only been confirmed as important diagnostic biomarkers for IBD.It also shows new prospects for treatment strategies for IBD.This article mainly describes the differences in miRNA expression between UC and CD,summarizes the relationship between miRNA and intestinal barrier,immune homeostasis and autophagy mechanism in the pathogenesis of IBD,and the re-search progress of miRNA involved in the diagnosis and treatment of IBD,so as to provide new insights for the development of IBD.关键词
炎症性肠病/发病机制/微小RNA(miRNA)/肠道屏障/免疫稳态/细胞自噬Key words
Inflammatory bowel disease/Pathogenesis/microRNA(miRNA)/Intestinal barrier/Immune homeostasis/Autophagy分类
医药卫生引用本文复制引用
陈沐莉,田元元,孙晓宁..微小RNA与炎症性肠病及其相关机制的研究进展[J].海南医学院学报,2024,30(2):139-147,9.基金项目
This study was supported by Natural Science Foundation Project of Hainan Province(821QN390) 海南省自然科学基金资助项目(821QN390) （821QN390）
