海南医学院学报2024，Vol.30Issue(2)：155-160,6.DOI:10.13210/j.cnki.jhmu.20231031.002
m6A修饰的circRNA在肝细胞癌中的研究进展
Advances of N6-methyladenosine modification on circular RNA in hepatocellular carcinoma
摘要
Abstract
N6-methyladenosine(m6A)is a reversible epigenetic modification,which is one of the most abundant modifi-ers in eukaryotic cells,and has been commonly reported in messenger RNAs and non-coding RNAs.The processing modification of m6A regulates RNA transcription,processing,splicing,degradation,and translation,and plays an important role in the biologi-cal process of tumors.Circular RNA,which lacks the 5'cap structure,has been mistakenly regarded as a"junk sequence"generat-ed by accidental shearing during the transcription process.However,it has been found that circRNAs can be involved in tumor in-vasion and metastasis through microRNAs,binding proteins,translated peptides,and m6A modifications.In this paper,we re-viewed the role of m6A modifications in circRNA regulation and their functions in hepatocellular carcinoma,and discussed their po-tential clinical applications and future development in this field.关键词
N6-甲基腺苷/环状RNA/修饰/肝细胞癌Key words
N6-methyladenosine/Circular RNA/Modification/Hepatocellular carcinoma分类
医药卫生引用本文复制引用
褚凤冉,刘路政,武金才..m6A修饰的circRNA在肝细胞癌中的研究进展[J].海南医学院学报,2024,30(2):155-160,6.基金项目
This study was supported by Key Project Research and Development Plan of Hainan Province(ZDYF2020134,ZDYF2022SHFZ283) （ZDYF2020134,ZDYF2022SHFZ283）
Natural Science Foundation of Hainan Province(821QN391) 海南省重点项目研发计划(ZDYF2020134,ZDYF2022SHFZ283) （821QN391）
海南省自然科学基金(821QN391) （821QN391）
