河北医学2024，Vol.30Issue(1)：65-70,6.DOI:10.3969/j.issn.1006-6233.2024.01.012
多因子降维法分析MTHFR C677T基因多态性-Hcy交互作用对高血压合并冠心病的影响
Analysis of the Impact of MTHFR C677T Gene Polymorphism-Hcy Interaction on Hypertension Complicated with Coronary Heart Disease Using Multifactor Dimensionality Reduction
摘要
Abstract
Objective:To analyze the effect of methylene tetrahydrofolate reductase(MTHFR)C677T gene polymorphism-Hcy interaction on hypertension combined with coronary heart disease based on multifactor dimension reduction(GMDR).Methods:A total of 150 hypertensive patients admitted to our hospital from March 2021 to October 2022 were selected as the study subjects.Based on coronary angiography results,they were divided into the isolated hypertension group(n= 51)and the hypertension complicated with coronary heart disease group(n=99).General information,Hcy levels,and MTHFR C677T gene polymorphism distri-bution were compared between the two groups.Logistic regression analysis was used to identify factors influen-cing hypertension complicated with coronary heart disease,and GMDR was employed to analyze the interaction between MTHFR C677T gene polymorphism and Hcy.Results:There was no statistically significant difference between the observed and theoretical values of MTHFR C677T genotypic frequencies in the two groups(P>0.05).The duration of hypertension,Hcy,LDL-C,MTHFR C677T genotypes(TT),and the T allele were i-dentified as influencing factors for hypertension complicated with coronary heart disease(P<0.05).GMDR results showed that the TT genotype of MTHFR C677T in interaction with Hcy formed the optimal model for the risk of hypertension complicated with coronary heart disease.The cross-validation consistency was 10/10,the testing accuracy was 75.00%,and the sign test P-value was 0.011.Conclusion:MTHFR C677T gene poly-morphism and the interaction with Hcy may increase the risk of coronary heart disease.Clinicians should dy-namically monitor changes in these indicators and take effective treatment measures promptly to reduce the oc-currence of coronary heart disease.关键词
高血压/冠心病/多因子降维法/MTHFR C677T基因多态性/同型半胱氨酸Key words
Hypertension/Coronary heart disease/Multi-factor dimensionality reduction method/MTHFR C677T gene polymorphism/Homocysteine引用本文复制引用
张明超,汪娟,鲁大胜,杨凌飞..多因子降维法分析MTHFR C677T基因多态性-Hcy交互作用对高血压合并冠心病的影响[J].河北医学,2024,30(1):65-70,6.基金项目
国家自然科学基金,(编号:国青81800445) （编号:国青81800445）
