连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β2-MG水平的影响OACSTPCD

Objective:To explore the effects of continuous blood purification(CBP)and intermittent hemodialysis(IHD)on levels of serum retinol-binding protein 4(RBP4),transferrin(Tf)and β2-micro-globulin(β2-MG)in elderly patients with acute renal failure(ARF).Methods:A total of 114 ARF patients admitted to our hospital from January 2021 to January 2023 were included in this study.The patients were ran-domly divided into two groups using a random number table,with 57 cases in each group(observation group and control group).The control group received IHD,and the observation group received CBP,with a dialysis period of 2 weeks for both groups.Clinical efficacy,serum levels[RBP4,Tf,β2-MG,Serum Creatinine(Scr),and Blood Urea Nitrogen(BUN)]before and 2 weeks after dialysis,as well as electrolyte indicators(K+,Cl-,Na+),were compared between the two groups.Complications during the treatment were recorded.Results:After dialysis,the total effective rates in the observation group and control group were 94.74%(54/57)and 78.95%(45/57),respectively,with a statistically significant difference(P<0.05).After 2 weeks of dialysis,the serum levels of RBP4,Tf,β2-MG,Scr,and BUN in both groups decreased significantly com-pared to before dialysis,and the reduction in the observation group was greater than that in the control group(P<0.05).After 2 weeks of dialysis,the serum levels of K+,Cl-,and Na+ in both groups increased signifi-cantly compared to before dialysis,and the increase in the observation group was greater than that in the con-trol group(P<0.05).The incidence of complications during dialysis in both groups(5.26%,7.02%)showed no significant difference(P>0.05).Conclusion:CBP is more effective in elderly ARF patients,ef-fectively removing small and large molecular toxins from the blood and maintaining electrolyte stability.