河北医学2024，Vol.30Issue(1)：71-75,5.DOI:10.3969/j.issn.1006-6233.2024.01.013
连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β2-MG水平的影响
Effects of Continuous Blood Purification and Intermittent Hemodialysis on Serum RBP4 Tf and β2-MG Levels in Elderly Patients with Acute Renal Failure
摘要
Abstract
Objective:To explore the effects of continuous blood purification(CBP)and intermittent hemodialysis(IHD)on levels of serum retinol-binding protein 4(RBP4),transferrin(Tf)and β2-micro-globulin(β2-MG)in elderly patients with acute renal failure(ARF).Methods:A total of 114 ARF patients admitted to our hospital from January 2021 to January 2023 were included in this study.The patients were ran-domly divided into two groups using a random number table,with 57 cases in each group(observation group and control group).The control group received IHD,and the observation group received CBP,with a dialysis period of 2 weeks for both groups.Clinical efficacy,serum levels[RBP4,Tf,β2-MG,Serum Creatinine(Scr),and Blood Urea Nitrogen(BUN)]before and 2 weeks after dialysis,as well as electrolyte indicators(K+,Cl-,Na+),were compared between the two groups.Complications during the treatment were recorded.Results:After dialysis,the total effective rates in the observation group and control group were 94.74%(54/57)and 78.95%(45/57),respectively,with a statistically significant difference(P<0.05).After 2 weeks of dialysis,the serum levels of RBP4,Tf,β2-MG,Scr,and BUN in both groups decreased significantly com-pared to before dialysis,and the reduction in the observation group was greater than that in the control group(P<0.05).After 2 weeks of dialysis,the serum levels of K+,Cl-,and Na+ in both groups increased signifi-cantly compared to before dialysis,and the increase in the observation group was greater than that in the con-trol group(P<0.05).The incidence of complications during dialysis in both groups(5.26%,7.02%)showed no significant difference(P>0.05).Conclusion:CBP is more effective in elderly ARF patients,ef-fectively removing small and large molecular toxins from the blood and maintaining electrolyte stability.关键词
急性肾功能衰竭/连续性血液净化/间歇性血液透析/视黄醇结合蛋白4/转铁蛋白/β2微球蛋白Key words
Acute renal failure/Continuous blood purification/Intermittent hemodialysis/Reti-nol-binding protein 4/Transferrin/β2-microglobulin.引用本文复制引用
何丽,张凡,程彩娟,曹路路,唐琪,李奕..连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β2-MG水平的影响[J].河北医学,2024,30(1):71-75,5.基金项目
四川省干部保健科研课题,(编号:川干研2021-1301) （编号:川干研2021-1301）
