河北医学2024，Vol.30Issue(1)：153-157,5.DOI:10.3969/j.issn.1006-6233.2024.01.030
两种抗感染药物治疗重症肺炎的效果及炎症因子水平预后比较
Comparison of the Effects of Two Anti-Infective Drugs on Severe Pneumonia,Inflammatory Factor Levels,and Prognosis
摘要
Abstract
Objective:To explore the effectiveness of piperacillin tazobactam and imipenem cilastatin so-dium in the treatment of severe pneumonia and their impact on inflammatory factor levels and prognosis.Methods:A total of 105 patients with severe pneumonia admitted to our hospital from January 2020 to March 2023 were selected.Using a random number table,they were divided into Group A(n=53)treated with imi-penem cilastatin sodium and Group B(n=52)treated with piperacillin tazobactam sodium.Clinical symptom disappearance times(cough,pulmonary shadow,pulmonary rales,temperature recovery time)were compared between the two groups.The severity[Clinical Pulmonary Infection Score(CPIS),Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ),Murray Lung Injury Score(MLIS)],blood gas parameters[oxygen saturation(SpO2),partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)],and levels of inflammatory factors[white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT)]were compared before and after 7 days of treatment.Adverse reactions were recorded.Results:Group B had shorter times for cough,disappearance of pulmonary shadow,pulmonary rales,and temperature recovery than Group A(P<0.05).After 7 days of treatment,both groups showed significant re-ductions in CPIS,APACHE Ⅱ,MLIS scores,PaCO2,and inflammatory factors(WBC,CRP,PCT),with larger reductions in Group B(P<0.05).Some blood gas parameters(SpO2,PaO2)significantly increased,with greater changes in Group B(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Piperacillin tazobactam sodium and imipenem cilastatin sodium can alleviate the condition and clinical symptoms of patients with severe pneumonia,improve blood gas conditions,and relieve inflammatory reactions.However,piperacillin tazobactam sodium shows bet-ter efficacy.关键词
重症肺炎/哌拉西林钠他唑巴坦/亚胺培南西司他丁钠/炎症因子/血气指标Key words
Severe pneumonia/Piperacillin sodium and tazobactam sodium/Imipenem and cilas-tatin sodium/Inflammatory factors/Blood gas indicators引用本文复制引用
王亮亮,王凯,曹继飞,尉玉杰..两种抗感染药物治疗重症肺炎的效果及炎症因子水平预后比较[J].河北医学,2024,30(1):153-157,5.基金项目
安徽省2021年度高校科学研究项目,(编号:KJ2021A0729) （编号:KJ2021A0729）
