表观代谢调控——中医药调控人体稳态研究的新方向OACSTPCD

Metabolic homeostasis is an important balance system in the body,including material synthesis balance and energy metabo-lism balance.An epigenetic metabolite is a type of metabolite that deviates from its classical function and is generated by simple and re-versible structural modifications of classical metabolites in the event of enzyme errors or chemical damage.This modification reaction is involved in various disease processes.Therefore,the modification/unmodification reaction between classical and epigenetic metabolites can be regarded as a new metabolic homeostasis in the body.Regulating epigenetic metabolic homeostasis may be an important link in the treatment mechanism of traditional Chinese medicine,and the difficulty in developing the theory of epigenetic metabolic regulation in traditional Chinese medicine mainly lies in methodology.The regulation of epigenetic metabolism is still a new topic in modern medical research,lacking a comprehensive research system.Although some mass spectrometry databases cover epigenetic metabolites,most of this information is based on structural prediction and lacks experimental confirmation.Currently,there are no available standard sub-stances for structural confirmation.Meanwhile,the concentration of apparent metabolites is often extremely low,and it is urgent to im-prove the sensitivity of detection methods.Therefore,for the construction of a systematic research strategy for the regulation of traditional Chinese medicine epigenetic metabolism,the following aspects should be included:(1)Improving the mass spectrometry database of epi-genetic metabolites,so that the epigenetic metabolic markers regulated by traditional Chinese medicine can be found in non targeted metabolomics methods.(2)In order to improve detection sensitivity,target epigenetic metabolites can be obtained through synthesis and structural modification methods,and targeted metabolomics methods can be constructed.Alternatively,based on the identification results of non targeted metabolites,targeted analysis methods can be established.(3)By combining transcriptomics,proteomics,or bioinformat-ics methods,analyze the molecular network of TCM epigenetic metabolism regulation,locate key regulatory enzymes,and determine their targets of action.