中医学报2024，Vol.39Issue(2)：273-276,4.DOI:10.16368/j.issn.1674-8999.2024.02.046
慢性髓系白血病急变期病机变化与治疗
Pathogenesis Evolution and Treatment of Chronic Myeloid Leukemia in Acute Phas
摘要
Abstract
From the theoretical analysis of collateral disease,chronic myeloid leukemia is characterized by the stagnation of collateral Qi in the early stage,abnormal biochemical changes in Ying Qi and Wei Qi,in which Phlegm and blood stasis are intertwined and the"Cheng Zhi"is weak;After intervention with anti-tumor drug TKI,chronic myeloid leukemia can be"Tiao Ping"and maintained in the chronic phase.As phlegm and blood stasis accumulate for a long time,blockages in the meridians can be observed,and a large number of microvessels are generated in the bone marrow micro-environment,providing nutritional support for leukemia cells.The activation of the Wnt pathway leads to the accumulation of β-catenin and activite the downstream genes,promotes the proliferation of leukemia cells,which becomes"out of control"at that point.This indicates the rapid transformation of chronic myeloid leukemia,and the progno-sis is often poor.At this point,intervention with traditional Chinese medicine for secondary"Tiao Ping"can improve clinical symptoms and enhance the quality of life of patients.关键词
慢性髓系白血病急变期/"承制调平"/络病/病机/大黄䗪虫丸Key words
acute phase of chronic myeloid leukemia/"Cheng Zhi Tiao Ping"theory/collateral disease/pathogenesis/Dahuang Zhe-chong Pill分类
医药卫生引用本文复制引用
周欣丽,闫理想,何敬,史哲新..慢性髓系白血病急变期病机变化与治疗[J].中医学报,2024,39(2):273-276,4.基金项目
天津市教委科研计划项目(2021KJ145) （2021KJ145）
天津市自然科学基金项目(21JCQNJC01210) （21JCQNJC01210）
天津中医药大学第一附属医院"拓新工程"基金项目(院2020057) （院2020057）
