中医学报2024，Vol.39Issue(2)：406-410,5.DOI:10.16368/j.issn.1674-8999.2024.02.067
加味半夏泻心汤联合PPIs降阶梯撤药对非糜烂性反流病寒热错杂证患者生活质量与焦虑抑郁状态的影响
Effect of Modified Banxia Xiexin Decoction and PPIs on Life Quality,Anxiety and Depression with Non-erosive Reflux Disease of Cold and Heat Syndrome
摘要
Abstract
Objective:To observe the effects of modified Banxia Xiexin Decoction combined with proton pump inhibitors(PPIs)on the quality of life,anxiety,and depression of patients with non-erosive reflux disease(NERD)with mixed Cold and Heat syndrome.Meth-od:88 NERD patients with mixed cold and heat syndrome were randomly divided into an observation group of 46 cases and a control group of 42 cases.The observation group was given modified Banxia Xiexin Decoction +PPIs step-down withdrawal,while the control group was given modified Banxia Xiexin Tang placebo +PPIs step-down withdrawal.Compare the therapeutic effects of traditional Chi-nese medicine syndromes before and after treatment between two groups of patients,including the visual analogue scale(VAS)for re-flux and heartburn,the GERD health-related quality of life(GERD_HRQL)scale for gastroesophageal reflux disease,the GERD pa-tient reported outcomes(GERD6RO)scale for gastroesophageal reflux disease,and the self rating anxiety scale(SAS)Self Rating De-pression Scale(SDS)scores and adverse reactions.Results:After 6 weeks of treatment,the observation group had an effective rate of 84.8%(39/46),while the control group had an effective rate of 64.3%(27/42).The difference in effective rates between the two groups was statistically significant(P<0.05).The VAS and SAS scores of the two groups of patients with heartburn after treatment for 2 weeks,4 weeks,and 6 weeks were lower than before treatment,and the observation group had lower scores than the control group dur-ing the same period,with statistical significance(P<0.05).GERD of reflux and heartburn in two groups of patients treated for 2 weeks,4 weeks,and 6 weeks.The HRQL scale scores were lower than before treatment,and the observation group had lower scores than the control group at 4 weeks and above 6 weeks of treatment,with statistical significance(P<0.05).Reflux VAS score,reflux and heartburn GERD of two groups of patients treated for 2 weeks,4 weeks,and 6 weeks.The PRO scale score and SDS score were both low-er than before treatment,and the observation group's score after 6 weeks of treatment was lower than that of the control group during the same period,with statistical significance(P<0.05).Neither group experienced any adverse reactions.Conclusion:The combination of modified Banxia Xiexin Decoction and PPIs step-down withdrawal therapy has a significant therapeutic effect on NERD with mixed Cold and Heat syndrome.It can effectively improve the quality of life and anxiety and depression of patients,with great safety.关键词
非糜烂性反流病/加味半夏泻心汤/质子泵抑制剂/降阶梯撤药/生活质量/焦虑抑郁状态/寒热错杂证Key words
non-erosive reflux disease/modified Banxia Xiexin Decoction/proton pump inhibitors/step down withdrawal of medica-tion/quality of life/anxiety and depression state/mixed Cold and Heat syndrome分类
医药卫生引用本文复制引用
万曌,时昭红,张书,刘凡..加味半夏泻心汤联合PPIs降阶梯撤药对非糜烂性反流病寒热错杂证患者生活质量与焦虑抑郁状态的影响[J].中医学报,2024,39(2):406-410,5.基金项目
国家重点研发计划项目(2019YFC1709604) （2019YFC1709604）
武汉市卫生健康委员会项目(WZ20C03) （WZ20C03）
