中医学报2024，Vol.39Issue(2)：416-420,5.DOI:10.16368/j.issn.1674-8999.2024.02.069
强肝胶囊对非酒精性脂肪肝肥胖患者糖脂代谢水平及肝功能的影响
Effect of Qianggan Capsule on Glucose and Lipid Metabolism and Liver Function of Non-alcoholic Fatty Liver Obese Patients
摘要
Abstract
Objective:To observe the effect of Qianggan Capsule on glucose and lipid metabolism levels and liver function in non-alco-holic fatty liver patients.Method:100 patients with non-alcoholic fatty liver obesity were evenly divided into a control group and an ob-servation group using a random number table method.The control group was treated with metformin,while the observation group was treated with metformin combined with Qianggan capsules.After 12 weeks of treatment,compare the glucose and lipid metabolism levels of two groups of patients before and after treatment[low-density lipoprotein cholesterol(LDL-C),triacylglycerol(TG),high-den-sity lipoprotein cholesterol(HDL-C),total cholesterol(TC),and fasting blood glucose(FBG)],Liver function indicators[gamma glutamyltransferase(GGT),alanine aminotransferase(ALT),alkaline phosphatase(ALP),aspartate aminotransferase(AST)],and the adverse reactions of the two groups of patients were compared.Results:(1)After treatment,the levels of ALT,AST,and GGT in both groups of patients significantly decreased(P<0.01);After treatment,the ALP of the observation group was(75.05±17.51)U·L-1 was significantly lower than the(83.71±20.41)U·L-1 before treatment in this group(P<0.05).(2)After treatment,the ALT and GGT of the observation group were(32.54±9.02)U·L-1 and(21.75±7.58)U·L-1,both significantly lower than those of the control group during the same period(P<0.01).(3)After treatment,the TG of the control group was(2.20±0.81)mmol·L-1 and HDL-C was(1.24±0.27)mmol·L-1.Compared with before treatment,the differences were statistically significant(P<0.01,P<0.05);The TC and TG of the observation group were(4.34±0.81)mmol·L-1 and(1.74±0.76)mmol·L-1,significantly lower than before treatment(P<0.01).(4)After treatment,the TG of the observation group was(1.74±0.76)mmol·L-1,signifi-cantly lower than that of the control group at the same period(2.20±0.81)mmol·L-1,and the difference was statistically significant(P<0.01).(5)The difference in FBG levels between the two groups after treatment and before treatment was statistically significant(P<0.05).(6)After treatment the difference of the degree of fatty liver of rank sum test results of the two groups of patients was sta-tistically significant(Z =-2.685,P<0.01).Conclusion:Qianggan Capsule can improve the glucose and lipid metabolism levels,pro-tect liver function,and reduce liver fat content in non-alcoholic fatty liver obese patients.关键词
非酒精性脂肪肝/强肝胶囊/二甲双胍/肥胖/糖脂代谢/肝功能Key words
non-alcoholic fatty liver/Qianggan Capsule/metformin/obesity/glycolipid metabolism/liver function分类
医药卫生引用本文复制引用
巴明玉,潘研,王娴,陈亚琳,燕树勋..强肝胶囊对非酒精性脂肪肝肥胖患者糖脂代谢水平及肝功能的影响[J].中医学报,2024,39(2):416-420,5.基金项目
河南中医药管理局中医药科学研究专项课题项目(2019JDZX076) （2019JDZX076）
河南省卫生健康委中医药科学研究专项课题项目(20-21ZY2163) （20-21ZY2163）
河南省中医药科学研究专项课题项目(2021JDZY084) （2021JDZY084）
