中医学报2024，Vol.39Issue(2)：437-439,3.DOI:10.16368/j.issn.1674-8999.2024.02.073
鳖甲煎丸治疗肝纤维化
Treatment of Liver Fibrosis with Biejiajian Pill
摘要
Abstract
Objective:To observe the clinical efficacy of Biejiajian Pill in treating liver fibrosis and analyze the objectivity of pulse radia-tion force imaging(ARFI)technology in evaluating its prevention and treatment of liver fibrosis.Method:62 patients with S2-S4 stage liver fibrosis were treated with Biejiajian Pill,and the liver fibrosis elasticity values before treatment,3 months of treatment,and 6 months of treatment were measured using ARFI.At the same time,correlation analysis was conducted on the four detection results of liv-er fibrosis in the three periods of patients.Results:(1)There were statistically significant differences(P<0.05)in the serological in-dicators before treatment,3 months after treatment,and 6 months after treatment with oral Biejiajian Pill.(2)The virtual touch tissue quantification(VTQ)values before treatment,3 months after treatment,and 6 months after treatment were 2.06±0.03,1.88±0.05,and 1.53±0.02,respectively,with statistically significant differences(P<0.01).(3)The correlation analysis between serum indica-tors and ARFI was conducted before treatment,3 months after treatment,and 6 months after treatment with oral Biejia decoction Pills.The VTQ value was significantly correlated with hyaluronic acid(P<0.01),and weakly correlated with typeⅣcollagen,typeⅢpro-collagen,and laminin(P<0.05).Conclusion:Biejiajian Pill has a significant therapeutic effect on liver fibrosis,and ARFI can be used to evaluate the objective efficacy of Biejiajian Pill in preventing and treating liver fibrosis.关键词
肝纤维化/鳖甲煎丸/脉冲辐射力成像技术Key words
liver fibrosis/Biejiajian Pill/pulse radiation force imaging technology分类
医药卫生引用本文复制引用
王飞,陈宝根..鳖甲煎丸治疗肝纤维化[J].中医学报,2024,39(2):437-439,3.基金项目
河南省中医管理局国家中医临床研究基地科研专项基金项目(2018JDZX045) （2018JDZX045）
