家畜生态学报2024，Vol.45Issue(1)：72-77,6.DOI:10.3969/j.issn.1673-1182.2024.01.011
河南省某兔场兔肝球虫和大肠杆菌混合感染情况及耐药性研究
Study on Mixed Infection and Drug Resistance of Rabbit Coccidia and Escherichia coli in a Rabbit Farm in Henan Province
摘要
Abstract
Rabbit hepatic coccidia and Escherichia coli are common and harmful diseases in rabbit feed-ing.In order to determine the pathogens resulting in rabbits diarrhea and mass death at a rabbit farm in Henan Province,the laboratory carried out pathological autopsy,parasite detection,tissue collection for i-solation and identification of pathogens and drug sensitivity test.The results showed that the number of coccidia detected in the feces of infected rabbits was less,which did not meet the standard of intestinal coc-cidia infection.Pathological examination showed that a few rabbits'liver had white strip nodular structure.A large number of coccidia oocysts were found in bile microscopic examination of all dissected rabbits.A suspected gram-negative rod pathogen was isolated and cultured.The size of the amplified fragment of eae gene was 833 bp,and the similarity with E.coli MN208178.1 was 99.65％.It was found that the isolated Escherichia coli was sensitive to polymyxin B,amikacin,ampicillin and cefoperazone,and had different degrees of resistance to other drugs.It is concluded that the main reason of large-scale morbidity and mor-tality in the rabbit farm is the mixed infection of hepatic coccidia and its secondary Escherichia coli.The results of this study provides scientific reference for the diagnosis and clinical medication of mixed infection of hepatic coccidia and Escherichia coli in rabbits.关键词
兔/肝球虫/大肠杆菌/耐药性Key words
rabbit/hepatic coccidia/Escherichia coli/drug resistance分类
农业科技引用本文复制引用
张昕,张自强,朱欣妍,张晨杰,刘玉梅..河南省某兔场兔肝球虫和大肠杆菌混合感染情况及耐药性研究[J].家畜生态学报,2024,45(1):72-77,6.基金项目
河南省重点研发与推广专项(192102110077和202102110093) （192102110077和202102110093）
