激光生物学报2023，Vol.32Issue(6)：492-501,10.DOI:10.3969/j.issn.1007-7146.2023.06.002
SARS-CoV-2突变株Omicron家族的演化传播和流行现状
Evolution,Transmission and Epidemic Status of SARS-CoV-2 Omicron Variant
摘要
Abstract
Coronaviruses(CoV)are enveloped viruses that possess a positive-sense single-stranded RNA genome 27～32 kb in length,belonging to the Coronaviridae family,the Nidovirales order.In recent years,coronaviruses have posed a great threat to human life and health.For example,in 2002 and 2012,severe acute respiratory syndrome coronavirus(SARS-CoV)and Mid-dle East respiratory syndrome coronavirus(MERS-CoV)emerged and caused panic,respectiverly.In particular,a novel corona-virus designated as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in 2019,has been epidemic so far worldwidely,seriously endangering human health and social order and arousing attention.So far,SARS-CoV-2 has evolved sev-eral variants.At present,the epidemic types are mainly Omicron family strains,and accompanying other variant strains.Mean-while,SARS-CoV-2 is still in constant variation.Nowadays,the epidemic situation prevention and control of our country has entered the stage of"category B disease"with normalization prevention and control,whereas SARS-CoV-2 will still be an im-portant public health issue in the future.In this review,the key mutations of various major strains of SARS-CoV-2 Omicron and their relationship with virus infectivity,pathogenicity,immune escape ability,and other characteristics were summarized,which can provide reference for the systematic understanding of SARS-CoV-2 evolution,transmission,and epidemic status.关键词
SARS-CoV-2/S蛋白/变异/感染致病/免疫逃逸Key words
SARS-CoV-2/S protein/variation/infection and disease/immune escape分类
医药卫生引用本文复制引用
郑嘉豪,王琼,练仲豪,黄勋..SARS-CoV-2突变株Omicron家族的演化传播和流行现状[J].激光生物学报,2023,32(6):492-501,10.基金项目
"感·动中国"医疗机构感染预防与控制科研项目(GY2023013-A). （GY2023013-A）
