激光生物学报2023，Vol.32Issue(6)：537-547,11.DOI:10.3969/j.issn.1007-7146.2023.06.006
哺乳动物病毒共受体的特征研究
A Study of Mammalian Viral Co-receptors Characteristics
摘要
Abstract
To investigate the common characteristics of mammalian virus co-receptors,this study collected 277 pairs of viral co-receptor combinations based on the data from ViralReceptor database.We investigated the structural,functional,evolutionary and tissue expression characteristics of mammalian virus co-receptors and compared them with combinations of viral receptors derived from different mammalian viruses,as well as randomly selected human proteins.The results showed that in comparison to other protein pairs,mammalian virus co-receptors exhibited higher functional similarity,higher ratio of interaction in the host protein interaction network,and higher co-expression levels in common human tissues.This study demonstrates that mammalian virus co-receptors share common features such as functionality,expression,and interaction,with the expectation that these find-ings will provide a reference for the discovery and identification of virus receptors.关键词
哺乳动物病毒/生物信息学/病毒共受体/病毒受体/人类蛋白组合Key words
mammalian virus/bioinformatic/virus co-receptor/virus receptor/human protein combination分类
生物科学引用本文复制引用
张征,彭友松..哺乳动物病毒共受体的特征研究[J].激光生物学报,2023,32(6):537-547,11.基金项目
国家自然科学基金项目(32170651) （32170651）
湖南省自然科学基金项目(2023JJ40323) （2023JJ40323）
湖南省教育厅科学研究项目(22C0097) （22C0097）
湖南省科技人才托举工程-"小荷"科技人才专项项目(2023TJ-X73) （2023TJ-X73）
湖南创新型省份建设专项项目(2021NK1011). （2021NK1011）
