中国当代医药2024，Vol.31Issue(1)：150-154,5.
司库奇尤单抗治疗伴潜伏性结核感染和乙型肝炎肝硬化的红皮病型银屑病1例并文献复习
A case of erythrodermic psoriasis with latent tuberculosis infection and hepatitis B cirrhosis treated with Secukinumab and literature review
房黎亚 1窦爱华 1宫模杰 1王宝林1
作者信息
- 1. 山东省枣庄市立医院皮肤科,山东枣庄 277100
- 折叠
摘要
Abstract
Due to the selective immunosuppressive effect of biological agents,long-term use in psoriasis patients may lead to reactivation of hepatitis B virus and mycobacterium tuberculosis.Clinical applications have found that Secukinumab is safer than other biological agents.This article retrospectively collected a case of erythrodermic psoriasis patient with latent tuberculosis infection and hepatitis B cirrhosis treated by Secukinumab,who suffered from bilateral femoral head necrosis due to irregular systematic use of hormones.After informed consent,the patient was given anti-hepatitis B virus and pre-ventive antituberculosis treatment.After that,the patient was given the standard protocol of Secukinumab and then bilateral total hip arthroplasty.At the 24th week of treatment,the patient's psoriasis area and severity index(PASI)reached 90;and at the 40th week,the patient reached PASI100,at the 60th week of treatment,the patient still reached PSAI90,with only the scaly erythema scattered in front of both tibia.Up to now,no hepatitis B virus replication and active tuberculosis have been found during follow-up.Through the introduction of this case and review of relevant literature,this article shows the effec-tiveness and safety of Secukinumab,and promote dermatologists'awareness of biological agents in improvement of metabolic comorbidity,hoping to make more patients with psoriasis accompanied by hepatitis B and tuberculosis obtain better clinical prognosis.关键词
红皮病型银屑病/潜伏性结核感染/乙型肝炎肝硬化/司库奇尤单抗/抗白介素-17AKey words
Erythrodermic psoriasis/Latent tuberculosis infection/Hepatitis B cirrhosis/Secukinumab/Anti inter-leukin-17A分类
医药卫生引用本文复制引用
房黎亚,窦爱华,宫模杰,王宝林..司库奇尤单抗治疗伴潜伏性结核感染和乙型肝炎肝硬化的红皮病型银屑病1例并文献复习[J].中国当代医药,2024,31(1):150-154,5.
