江苏大学学报（医学版）2024，Vol.34Issue(1)：57-60,4.DOI:10.13312/j.issn.1671-7783.y230121
血小板内皮细胞黏附分子1和平滑肌肌动蛋白对瘢痕疙瘩综合治疗预后的影响
Effect of PECAM-1 and SMA on the prognosis of keloid after comprehensive treatment
摘要
Abstract
Objective:To explore the effect of the expression levels of platelet endothelial cell adhesion molecule-1(PECAM-1)and smooth muscle actin(SMA)in the blood vessels of keloid on the prognosis of comprehensive treatment of keloid.Methods:From August 2020 to June 2022,a total of 61 patients with keloids diagnosed and treated in the Department of Dermatology,Affiliated Hospital of Jiangsu University were retrospectively analyzed,with a total of 69 keloids.All patients received comprehensive treatment of surgical resection and 90Sr isotope application.Immunohistochemical staining was used to detect the expression levels of PECAM-1 and SMA in blood vessels of surgically resected keloid specimens.All patients were followed up for 6 months by telephone and outpatient service.Results:A total of 19(27.5％)keloids recurred within 6 months,and 11(15.9％)had adverse reactions after 90Sr isotope application.The high expression rates of PECAM-1 and SMA in the recurrence group were higher than those in the non-relapse group(x2=7.496,P=0.006;x2=5.197,P=0.023);the incidence of adverse reactions after treatment had no significant association with the expression levels of PECAM-1 and SMA(x2=0.172,P=0.935;x2=1.110,P=0.484).Conclusion:The expression levels of PECAM-1 and SMA in keloid blood vessels were negatively correlated with the prognosis of comprehensive treatment,and they may be potential indicators for judging the prognosis of keloid.关键词
瘢痕疙瘩/放射性核素敷贴治疗/免疫组织化学染色/血小板内皮细胞黏附分子1/平滑肌肌动蛋白Key words
keloid/radionuclide application therapy/immunohistochemical staining/platelet endothelial cell adhesion molecule-1/smooth muscle actin分类
医药卫生引用本文复制引用
羊逸飞,许辉,龙卫国,李遇梅..血小板内皮细胞黏附分子1和平滑肌肌动蛋白对瘢痕疙瘩综合治疗预后的影响[J].江苏大学学报（医学版）,2024,34(1):57-60,4.基金项目
国家自然科学基金资助项目(81573053) （81573053）
江苏省医学重点学科建设单位(JSDW202229) （JSDW202229）
