兰州大学学报（医学版）2023，Vol.49Issue(11)：33-41,9.DOI:10.13885/j.issn.1000-2812.2023.11.005
胆管癌患者微量金属质量分数与肿瘤进展的关系
Relationship between trace metal levels and tumor progression in patients with cholangiocarcinoma
摘要
Abstract
Objective To investigate the difference in the distribution of trace metals in tumor tissues and adja-cent healthy tissues in patients with cholangiocarcinoma,and to analyze their relationship with the degree of tumor differentiation and lymph node metastasis,so as to provide evidence for targeted therapy of cholangio-carcinoma.Methods Inpatients admitted into The First Hospital of Lanzhou University from January 2012 to December 2015 and diagnosed with cholangiocarcinoma by pathological testing were selected as the study subjects,the paired tumors and adjacent healthy tissues were collected during surgery,and the levels of eight trace metals including Cd,Co,Fe,Mn,Ni,Pb,Se and Zn were analyzed by inductively coupled plasma mass spectrometry.Logistic regression and Bayesian kernel regression models were used to investigate the relation-ship between trace metals and the degree of tumor differentiation and lymph node metastasis of cholangiocar-cinoma.Results The tumor tissue showed lower concentrations of Cd,Co,Fe and Ni than the control group(P<0.05).In addition,the study found that cholangiocarcinoma patients with poorly differentiated tumors and positive lymph node metastases had lower tissue levels of Cd,Fe,Ni,and Pb(P<0.05),and Cd(OR = 1.00,95%CI:[0.99,1.00])and Fe concentration(OR = 0.97,95%CI:[0.94,0.99])was negatively correlated with the differentiation degree of cholangiocarcinoma(P<0.05).The Bayesian kernel regression model showed that mixed metal levels were significantly negatively correlated with the degree of tumor differentiation and lymph node metastasis in patients with cholangiocarcinoma,and Cd and Ni were the most contributing metals.Conclusion The change of trace metal level may be related to the progression of cholangiocarcinoma,which could provide evidence for clinical treatment of patients with cholangiocarcinoma.关键词
胆管癌/微量金属/肿瘤组织/肿瘤旁组织/肿瘤分化不良/淋巴结转移/镉/铁/镍Key words
cholangiocarcinoma/trace metal/tumor tissue/adjacent healthy tissue/poor tumor differentiation/lymph node metastasis/cadmium/fetal/nickel分类
医药卫生引用本文复制引用
张宏龙,严俊,李汛..胆管癌患者微量金属质量分数与肿瘤进展的关系[J].兰州大学学报（医学版）,2023,49(11):33-41,9.基金项目
国家自然科学基金资助项目(32060289,32171610) （32060289,32171610）
甘肃省自然科学基金资助项目(20JR10RA699) （20JR10RA699）
