临床肝胆病杂志2024，Vol.40Issue(1)：52-57,6.DOI:10.12449/JCH240110
Mindin蛋白在经聚乙二醇干扰素α-2b治疗的慢性乙型肝炎中的动态变化及意义
Dynamic change and significance of Mindin protein in chronic hepatitis B treated with PEG-IFNα-2b
摘要
Abstract
Objective To investigate the change and potential role of Mindin protein in the treatment of chronic hepatitis B(CHB)with PEG-IFNα-2b.Methods A total of 29 CHB patients who received the treatment with PEG-IFNα-2b in The Second Affiliated Hospital of Xi'an Jiaotong University from January 2018 to December 2019 were enrolled,and according to their clinical outcome,they were divided into cured group with 17 patients and uncured group with 12 patients.Peripheral blood samples were collected from both groups at baseline,12 weeks,and 24 weeks to measure blood routine indices,liver function parameters,hepatitis B markers,and Mindin protein.HBsAg,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and Mindin protein at different time points were compared between the two groups.The independent-samples t test was used for comparison of normally distributed continuous data between two groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups;a Spearman correlation analysis was used to investigate correlation;a multiple linear regression analysis was used to investigate the influence of HBsAg and ALT on the content of Mindin protein.Results The analysis of baseline data showed that there were significant differences in the levels of HBsAg,HBeAb,albumin,and albumin/globulin ratio between the cured group and the uncured group(all P<0.05).The cured group tended to have a gradual increase in the level of Mindin,and the level of Mindin at 24 weeks was significantly higher than that at baseline(P<0.05).The cured group had a significantly higher level of Mindin protein than the uncured group at 24 weeks(P=0.019).The cured group had a significantly lower level of HBsAg than the uncured group(P<0.05),with a significant change from baseline to each time point within the cured group(P<0.05).In addition,the levels of ALT and AST in the cured group tended to first increase and then decrease,and the expression levels at 12 weeks were significantly higher than those at baseline(P<0.05).At 12 weeks,there was a strong linear correlation between Mindin protein levels and ALT in the untreated group(r=0.760 8,P<0.05),and further multiple linear regression analysis also demonstrated a linear relationship between the two(b=1.571,P=0.019).Conclusion There is a significant difference in the level of Mindin protein between the cured group and the non-cured group after 24 weeks of PEG-IFNα-2b antiviral treatment,and therefore,detecting the dynamic changes of Mindin protein can better predict the treatment outcome of CHB,which provides a reference for clinical practice.关键词
乙型肝炎,慢性/Mindin蛋白/干扰素αKey words
Hepatitis B,Chronic/Mindin Protein/Interferon-alpha引用本文复制引用
王怡恺,吴凤萍,刘晨瑞,郝苗,吕莎莎,张苗苗,党双锁,张欣..Mindin蛋白在经聚乙二醇干扰素α-2b治疗的慢性乙型肝炎中的动态变化及意义[J].临床肝胆病杂志,2024,40(1):52-57,6.基金项目
陕西省自然科学基金(2022JCYB-770) Natural Science Foundation of Shaanxi Province(2022JCYB-770) （2022JCYB-770）
