临床肝胆病杂志2024，Vol.40Issue(1)：89-95,7.DOI:10.12449/JCH240116
经皮经肝胃冠状静脉栓塞术单独或联合部分脾动脉栓塞术治疗肝硬化门静脉高压出血效果比较的Meta分析
Efficacy of percutaneous transhepatic variceal embolization alone or in combination with partial splenic embolization in treatment of portal hypertensive hemorrhage in liver cirrhosis:A Meta-analysis
摘要
Abstract
Objective To investigate the efficacy of percutaneous transhepatic variceal embolization(PTVE)alone or in combination with partial splenic embolization(PSE)in the treatment of portal hypertensive hemorrhage in liver cirrhosis through a meta-analysis.Methods This study was conducted according to PRISMA guideline,with a PROSPERO registration number of CRD42023396690.Wanfang Med Online,CNKI,CBM,VIP Databases,PubMed,Embase,the Cochrane Library,and Web of Science databases were searched for articles on PTVE alone or in combination with PSE in the treatment of portal hypertensive hemorrhage in liver cirrhosis published up to December 23,2022.The articles were selected based on inclusion and exclusion criteria,and related data were extracted.The RevMan 5.4.1 statistical analysis software was used to perform the meta-analysis.Results Eight articles were finally included,with a total sample size of 592 cases,among which there were 316 cases in the PTVE+PSE group and 276 cases in the PTVE group.The meta-analysis showed that compared with the PTVE group,the PTVE+PSE group had significantly lower postoperative portal vein pressure(standardized mean difference[SMD]=-1.75,95%confidence interval[CI]:-2.33 to-1.16,P<0.05),postoperative diameter of the portal vein(SMD=-0.87,95%CI:-1.64 to-0.10,P<0.05),postoperative rebleeding rate(odds ratio[OR]=0.17,95%CI:0.11—0.28,P<0.05),mortality rate(OR=0.13,95%CI:0.04—0.37,P<0.05),and incidence rate of postoperative portal hypertensive gastrointestinal disease(OR=0.17,95%CI:0.07—0.45,P<0.05],as well as a significantly higher postoperative platelet level(SMD=0.79,95%CI:0.52—1.06,P<0.05),while there were no significant differences between the two groups in the incidence rates of postoperative ascites.Conclusion Compared with PTVE alone,PTVE combined with PSE can effectively reduce the rebleeding rate and mortality rate of portal hypertensive hemorrhage in liver cirrhosis,the incidence rate of portal hypertensive gastrointestinal disease,and portal vein pressure,and it can also shorten the diameter of the portal vein and increase platelet level.Therefore,it is an effective interventional method for the treatment of portal hypertension hemorrhage in liver cirrhosis.关键词
肝硬化/高血压,门静脉/出血/治疗结果/Meta分析Key words
Liver Cirrhosis/Hypertension,Portal/Hemorrhage/Treatment Outcome/Meta-Analysis引用本文复制引用
朱军源,夏翊夫,杜艳梅,张春清..经皮经肝胃冠状静脉栓塞术单独或联合部分脾动脉栓塞术治疗肝硬化门静脉高压出血效果比较的Meta分析[J].临床肝胆病杂志,2024,40(1):89-95,7.基金项目
国家自然科学基金(81970533,81770606) National Natural Science Foundation of China(81970533,81770606) （81970533,81770606）
