临床肝胆病杂志2024，Vol.40Issue(1)：147-150,4.DOI:10.12449/JCH240124
肝线粒体功能障碍在非酒精性脂肪性肝病发病中的作用机制
The mechanism of action of mitochondrial dysfunction in the development of non-alcoholic fatty liver disease
摘要
Abstract
Nonalcoholic fatty liver disease(NAFLD)has gradually become the main reason affecting human liver health,and many factors are involved in the development and progression of NAFLD.Mitochondria,as the"energy factory"of cells,plays an important role in maintaining normal physiological functions.Studies have shown that hepatic mitochondrial dysfunction promotes the development and progression of NAFLD.This article briefly introduces the latest research advances in the basic characteristics and physiological function of liver mitochondria and reviews new research findings in the association of mitochondrial dysfunction with obesity,simple fatty liver disease,and nonalcoholic steatohepatitis,in order to provide new ideas for the research on targeted mitochondrial therapy for NAFLD.关键词
非酒精性脂肪性肝病/线粒体,肝/氧化磷酸化/线粒体疾病Key words
Non-alcoholic Fatty Liver Disease/Mitochondria,Liver/Oxidative Phosphorylation/Mitochondrial Diseases引用本文复制引用
杨冰清,尹静亚,王琦..肝线粒体功能障碍在非酒精性脂肪性肝病发病中的作用机制[J].临床肝胆病杂志,2024,40(1):147-150,4.基金项目
国家自然科学基金面上项目(82170591) National Natural Science Foundation of China(82170591) （82170591）
