临床肝胆病杂志2024，Vol.40Issue(1)：157-160,4.DOI:10.12449/JCH240126
巨噬细胞在原发性胆汁性胆管炎发病中的作用机制及影响
The role and impact of macrophages in the pathogenesis of primary biliary cholangitis
摘要
Abstract
Primary biliary cholangitis(PBC)is a chronic autoimmune disease of cholestasis in which immune factors lead to progressive small bile duct destruction,cholestasis,and eventually liver fibrosis,liver cirrhosis,and even liver failure.Macrophages,as a group with functional heterogeneity,play different roles in the whole disease process of PBC.This article summarizes the possible ways by which macrophages are involved in the pathogenesis of PBC and discusses their impact on the disease and the potential therapeutic targets of macrophages.It is pointed out that macrophages are mainly involved in innate immunity in PBC injury and are associated with gut microbiota dysbiosis,and they are also associated with cholestasis,liver fibrosis,and liver cirrhosis in the later stages of the disease.关键词
原发性胆汁性胆管炎/巨噬细胞/病理过程Key words
Primary Biliary Cholangitis/Macrophages/Pathologic Processes引用本文复制引用
马狄,邰文琳..巨噬细胞在原发性胆汁性胆管炎发病中的作用机制及影响[J].临床肝胆病杂志,2024,40(1):157-160,4.基金项目
国家自然科学基金(82060385) （82060385）
昆明医科大学2023年研究生创新基金(2023S321) National Natural Science Foundation of China(82060385) （2023S321）
The Postgraduate Innovation Fund Project of Kunming Medical University 2023(2023S321) （2023S321）
