临床眼科杂志2023，Vol.31Issue(6)：481-487,7.DOI:10.3969/j.issn.1006-8422.2023.06.001
基于OCTA观察近视人群长时间近距离学习前后视网膜微循环血流的变化情况
Association of changes in retinal microcirculation blood flow before and after long-term short-distance learn-ing in myopic population based on OCTA
摘要
Abstract
Objective To observe the changes of retinal microcirculation blood flow before and after long-term(＞30 min)short-distance(＜30 cm)learning in people with different degrees of myopia by optical coherence tomography an-giography(OCTA).Methods A cross-sectional case-control study.240 medical students who only wore spectacles from August 2021 to April 2022 were randomly selected and were divided into three groups according to the difference of equiva-lent spherical lenses,of which 79 cases were in the low myopia group(-0.5 D～-3 D),85 cases of moderate myopia group(-3 D～-6 D),and 76 cases of high myopia group(＞-6 D).The subjects were scanned by OCTA at 3 time points after sufficient rest,that is,before learning,after long-term(＞30 min)short-range(＜30 cm)learning,andafter 15 minutes of staring into the distance.The foveal avascular zone(FAZ),the perimeter(PERIM),the area of the eye ax-is/blood flow blank area(AL/FD),the outer and superficial retinal capillaries(flow out,flow cap),the thickness of the optic nerve fiber layer(RNFL),optic disc and peripheral blood flow density(CPVD)and other parameters and their changes were analyzed.Results There was no significant difference in age and gender among the three groups(P＞0.05).Comparing the area and perimeter(PERIM)of the macular area of the three groups of eyes,the FAZ area gradual-ly increased,and the difference was statistically significant(H=208.7,H=197.043,P＜0.001,P＜0.001).The difference of flow out,flow cap,RNFL,and CPVD gradually decreased between the three groups of eyes(H=173.028,H=156.773,H=174.270,H=119.571,P＜0.001,P＜0.001,P＜0.001,P＜0.001).After a long(＞30 min)close-distance(＜30 cm)study,the three groups of subjects had lower flow out,flow cap,and CPVD than before the study(P＜0.001,P＜0.001,P＜0.001).After each of the three groups performed a 15 minutes gazing from the dis-tance,the difference of indexes of the low myopia group and the moderate myopia group was not statistically significant(P＞0.05),but the high myopia group was statistically significant(P＜0.001).Conclusions The OCTA examination showed that the overall blood flow density of the macular area of the retina in patients with myopia after high-intensity eye use decreased,and it could be recovered to a certain extent after resting from far viewing.Indicators of retinal microvascu-lar changes in patients.关键词
近视/相干光层析血管成像术/视网膜微循环/血流密度Key words
Myopia/Optical coherence tomography angiography/Retinal microcirculatio/Blood flow density引用本文复制引用
申洁,范宇晨,代应辉,岳晓丽..基于OCTA观察近视人群长时间近距离学习前后视网膜微循环血流的变化情况[J].临床眼科杂志,2023,31(6):481-487,7.基金项目
安徽省高校自然科学科研项目重点项目(KJ2021A0766) （KJ2021A0766）
